Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/9715

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dc.contributor.authorAzevedo, N. F.-
dc.contributor.authorLopes, Susana Patrícia-
dc.contributor.authorKeevil, C. W.-
dc.contributor.authorPereira, Maria Olívia-
dc.contributor.authorVieira, M. J.-
dc.date.accessioned2009-11-10T14:36:03Z-
dc.date.available2009-11-10T14:36:03Z-
dc.date.issued2009-04-
dc.date.submitted2008-
dc.identifier.citation"Biotechnology Letters". ISSN 0141-5492. 31:4 (2009) 477-485.por
dc.identifier.issn0141-5492por
dc.identifier.urihttp://hdl.handle.net/1822/9715-
dc.description.abstractIn nature, the biofilm mode of life is of great importance in the cell cycle for many microorganisms. Perhaps because of biofilm complexity and variability, the characterization of a given microbial system, in terms of biofilm formation potential, structure and associated physiological activity, in a large-scale, standardized and systematic manner has been hindered by the absence of high-throughput methods. This outlook is now starting to change as new methods involving the utilization of microtiter-plates and automated spectrophotometry and microscopy systems are being developed to perform large-scale testing of microbial biofilms. Here, we evaluate if the time is ripe to start an integrated omics approach, i.e., the generation and interrogation of large datasets, to biofilms—‘‘biofomics’’. This omics approach would bring much needed insight into how biofilm formation ability is affected by a number of environmental, physiological and mutational factors and how these factors interplay between themselves in a standardized manner. This could then lead to the creation of a database where biofilm signatures are identified and interrogated. Nevertheless, and before embarking on such an enterprise, the selection of a versatile, robust, high-throughput biofilm growing device and of appropriate methods for biofilm analysis will have to be performed. Whether such device and analytical methods are already available, particularly for complex heterotrophic biofilms is, however, very debatable.por
dc.language.isoengpor
dc.publisherSpringerpor
dc.rightsopenAccesspor
dc.subjectBiofomicspor
dc.subjectHigh-throughputpor
dc.subjectSystems biologypor
dc.subjectBiofilmspor
dc.subjectDatabasepor
dc.titleTime to ‘‘go large’’ on biofilm research : advantages of an omics approachpor
dc.typearticlepor
dc.peerreviewedyespor
sdum.number4por
sdum.pagination477–485por
sdum.publicationstatuspublishedpor
sdum.volume31por
oaire.citationStartPage477por
oaire.citationEndPage485por
oaire.citationIssue4por
oaire.citationVolume31por
dc.identifier.doi10.1007/s10529-008-9901-4por
dc.identifier.pmid19116693por
dc.subject.wosScience & Technologypor
sdum.journalBiotechnology Letterspor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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