Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/9407
Título: | DODAB and DODAC bilayer-like aggregates in the micromolar surfactant concentration domain |
Autor(es): | Feitosa, Eloi Alves, Fernanda Rosa Castanheira, Elisabete M. S. Oliveira, M. Elisabete |
Palavras-chave: | DODAB DODAC DSC Nile Red Cationic vesicles Melting temperature Steady-state fluorescence Cationic vesicle |
Data: | 10-Fev-2009 |
Editora: | Springer |
Revista: | Colloid and Polymer Science |
Citação: | "Colloid and Polymer Science". ISSN 0303-402X. 287:5 (2009) 591-599. |
Resumo(s): | In the millimolar concentration domain (typically 1 mM), dioctadecyldimethylammonium bromide and chloride (DODAX, X representing Br- or Cl- counterions) molecules assemble in water as large unilamellar vesicles. Differential scanning calorimetry (DSC) is a suitable technique to obtain the melting temperature (Tm) characteristic of surfactant bilayers, while fluorescence spectroscopy detects formation of surfactant aggregates, like bilayers. These two techniques were combined to investigate the assemble of DODAX molecules at micromolar concentrations, from 10 to 100 micromolar. At 1 mM surfactant, Tm ~ 45 ºC and 49 oC, respectively for DODAB and DODAC. DSC and fluorescence of Nile Red were used to show the formation of DODAX aggregates, at the surfactant concentration as low as 10 micromolar, whose Tm decreases monotonically with increasing DODAX concentration to attain the value for the ordinary vesicles. The data indicate that these aggregates are organized as bilayer-like structures. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/9407 |
DOI: | 10.1007/s00396-009-2008-1 |
ISSN: | 0303-402X 1435-1536 |
Versão da editora: | www.springerlink.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
2009 (DODAB microvesículos).pdf | Documento Principal | 305,77 kB | Adobe PDF | Ver/Abrir |