Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/9006

TitleSignificance of osteopontin expression in human invasive breast tumour stroma
Author(s)Rodrigues, L. R.
Lopes, Nair
Sousa, Bárbara
Vieira, Daniella
Milanezi, Fernanda
Paulsson, Marie
Lindmark-Mässon, Helena
Teixeira, J. A.
Schmitt, Fernando C.
KeywordsOsteopontin
Tumour stroma
Invasive breast cancer
Issue date5-May-2009
PublisherBentham Open
JournalThe Open Breast Cancer Journal
Citation"The Open Breast Cancer Journal". ISSN 1876-8172. 1 (2009) 1-9.
Abstract(s)Osteopontin has been reported to stimulate cell adhesion, migration and specific signalling functions. Its overexpression has been found in melanoma, breast, lung, colorectal, stomach and ovarian cancer. However, its overexpression and role in human breast cancer remains to be elucidated. In this study, invasive breast tumours from 129 patients were examined by immunohistochemistry in order to assess osteopontin association with several molecular tumour markers. Additionally, its relationship with proliferation and angiogenesis was determined. Ultimately, other tumour variables such as histological grade, tumour size and nodal status were also assessed. Results achieved showed that no statistical significant association exists between osteopontin expression and major clinicopathological parameters or angiogenesis, except for the number of lymph nodes involved. However, a correlation with some molecular markers was observed, namely with P-Cadherin, EGFR, cytokeratin 14 and vimentin. Additionally, higher proliferation rates were found for the tumours expressing osteopontin. Although several studies refer osteopontin as a potential breast cancer biomarker, it is still not clear if it can provide important diagnosis information, evaluate treatment effects or assess the potential for metastatic disease in patients.
TypeArticle
URIhttp://hdl.handle.net/1822/9006
ISSN1876-8172
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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