Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/8922

TitleNew dextrin-vinylacrylate hydrogel : studies on protein diffusion and release
Author(s)Carvalho, Joana
Coimbra, Manuel A.
Gama, F. M.
KeywordsDextrin
Drug release
Hydrogel
Issue dateJan-2009
PublisherElsevier
JournalCarbohydrate Polymers
Citation"Carbohydrate Polymers". ISSN 0144-8617. 75 :2 (Jan. 2009) 322-327.
Abstract(s)New dextrin hydrogels with degrees of substitution (DS) from ca. 10% (DS 10) to 70% (DS 70) were prepared by radical polymerization of aqueous solutions of vinylacrylate (VA)-derivatized dextrin. A preliminary analysis on the potential of these hydrogels for the controlled release of bioactive molecules was carried out. The protein (bovine serum albumin) diffusion coefficients on the hydrogels were calculated using the lag-time analysis. Values in range 10−7 cm2/s were obtained for DS 20 and DS 40 and a smaller value of 10−8 cm2/s arised upon DS increasing to 70%, revealing the dependence of the diffusivity on the crosslinking density. The release of BSA from dextrin-VA hydrogels, in the presence of amyloglucosidase was shown to be mainly dependent on the diffusion and, to a smaller extent, on the degradation kinetics. The protein release can be tailored from days to months by varying the DS.
TypeArticle
URIhttp://hdl.handle.net/1822/8922
DOI10.1016/j.carbpol.2008.07.033
ISSN0144-8617
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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