Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/89170
Título: | Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury |
Autor(es): | Duarte, Diogo Correia, Cátia Reis, R. L. Pashkuleva, I. Peixoto, Daniela Alves, N. M. |
Palavras-chave: | Adhesive hydrogels Hyaluronic acid Ibuprofen Neuronal regeneration Spinal cord injury |
Data: | Fev-2024 |
Editora: | American Chemical Society |
Revista: | Biomacromolecules |
Citação: | Duarte D., Correia C., Reis R. L., Pashkuleva I., Peixoto D., Alves N. M. Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury, Biomacromolecules, pp. in press, doi:10.1021/acs.biomac.3c01186, 2024 |
Resumo(s): | Spinal cord injuries (SCI) have devastating physical, psychological, and psycho-social consequences for patients. One challenge of nerve tissue repair is the lack of a natural extracellular matrix (ECM) that guides the regenerating axons. Hyaluronic acid (HA) is a major ECM component and plays a fundamental role in facilitating lesion healing. Herein, we developed HA-based adhesive hydrogels by modification of HA with dopamine, a mussel-inspired compound with excellent adhesive properties in anaqueous environment. The hydrogels were loaded with the anti-inflammatory drug ibuprofen and the response of neuronal cells (SH-SY5Y) was evaluated in terms of viability, morphology, and adhesion.The obtained results suggested that the developed materials can bridge lesion gaps, guide axonal growth, and simultaneously act as a vehicle for the delivery of bioactive compounds. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/89170 |
DOI: | 10.1021/acs.biomac.3c01186 |
ISSN: | 1525-7797 |
e-ISSN: | 1526-4602 |
Versão da editora: | https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.3c01186 |
Arbitragem científica: | yes |
Acesso: | Acesso embargado (1 Ano) |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21071-duarte-et-al-2024-bioadhesive-hyaluronic-acid-based-hydrogels-spinal-cord-injury.pdf Até 2025-03-01 | 8,51 MB | Adobe PDF | Ver/Abrir |