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|Title:||Synthesis and antitumour evaluation of benzopsoralen analogues|
|Author(s):||Oliveira, Ana M. A. G.|
Campos, Ana M. F. Oliveira
Rodrigues, Lígia M.
Raposo, M. Manuela M.
Machado, António E. H.
Nascimento, Maria São José
|Journal:||Chemistry & Biodiversity|
|Citation:||"Chemistry & Biodiversity." ISSN 1612-1872. 4:5 (May 2007) 980-990.|
|Abstract(s):||The synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of the final products was evaluated and is discussed in terms of the 3D-geometry and electronic density distribution. The compounds showing significant biological activity in this study were those having angular structures.|
|Appears in Collections:||CDQuim - Artigos (Papers)|
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