Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/8646

TitleSynthesis and antitumour evaluation of benzopsoralen analogues
Author(s)Oliveira, Ana M. A. G.
Campos, Ana M. F. Oliveira
Rodrigues, Lígia M.
Raposo, M. Manuela M.
Machado, António E. H.
Nascimento, Maria São José
Nazareth, N.
Pinto, Madalena
KeywordsPsoralens
Xanthen-9-one
Carbazole
Antitumour
Coumarin
Issue dateMay-2007
PublisherWiley
JournalChemistry & Biodiversity
Citation"Chemistry & Biodiversity." ISSN 1612-1872. 4:5 (May 2007) 980-990.
Abstract(s)The synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of the final products was evaluated and is discussed in terms of the 3D-geometry and electronic density distribution. The compounds showing significant biological activity in this study were those having angular structures.
TypeArticle
URIhttp://hdl.handle.net/1822/8646
DOI10.1002/cbdv.200790089
ISSN1612-1872
1612-1880
Publisher versionwww.interscience.wiley.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
Xantonas.pdfDocumento Principal190,67 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID