Please use this identifier to cite or link to this item:

Title2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids
Author(s)Soares, Ana M. S.
Costa, Susana P. G.
Gonçalves, M. Sameiro T.
Amino acids
Photocleavable protecting groups
Issue date2010
JournalAmino Acids
CitationSoares, A.M.S., Costa, S.P.G. & Gonçalves, M.S.T. 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids. Amino Acids 39, 121–133 (2010).
Abstract(s)Aiming at the development of new benzopyran-based photocleavable protecting groups, novel chloromethylated and hydroxymethylated 2-oxo-2H-benzo[h]benzopyran derivatives bearing a methoxy substituent were designed and used in the synthesis of a series of fluorescent bioconjugates, by linking through an ester or urethane bond to several model neurotransmitter amino acids (glycine, alanine, beta-alanine and gamma-aminobutyric acid, GABA). The resulting fluorescent bioconjugates with emission in the visible range and high fluorescent quantum yields, were subjected to photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300, 350 and 419 nm) and photocleavage kinetic data were obtained.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
Final revised manuscript.pdf
  Restricted access
Author's Accepted Manuscript572,52 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID