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|Title:||2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids|
|Author(s):||Soares, Ana M. S.|
Costa, Susana P. G.
Gonçalves, M. Sameiro T.
Photocleavable protecting groups
|Citation:||Soares, A.M.S., Costa, S.P.G. & Gonçalves, M.S.T. 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids. Amino Acids 39, 121–133 (2010). https://doi.org/10.1007/s00726-009-0383-z|
|Abstract(s):||Aiming at the development of new benzopyran-based photocleavable protecting groups, novel chloromethylated and hydroxymethylated 2-oxo-2H-benzo[h]benzopyran derivatives bearing a methoxy substituent were designed and used in the synthesis of a series of fluorescent bioconjugates, by linking through an ester or urethane bond to several model neurotransmitter amino acids (glycine, alanine, beta-alanine and gamma-aminobutyric acid, GABA). The resulting fluorescent bioconjugates with emission in the visible range and high fluorescent quantum yields, were subjected to photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300, 350 and 419 nm) and photocleavage kinetic data were obtained.|
|Access:||Restricted access (UMinho)|
|Appears in Collections:||CDQuim - Artigos (Papers)|
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|Final revised manuscript.pdf|
|Author's Accepted Manuscript||572,52 kB||Adobe PDF||View/Open|