Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/8357

TitleCharacterization of the self-assembly process of hydrophobically modified dextrin
Author(s)Gonçalves, Catarina
Gama, F. M.
KeywordsDextrin
Nanoparticles
Self-assembly
Hydrophobic domains
Issue dateNov-2008
PublisherElsevier
JournalEuropean Polymer Journal
Citation“European Polymer Journal”. ISSN 0014-3057. 44:11 (2008) 3529–3534.
Abstract(s)Hydrophobized dextrin, randomly substituted by long alkyl chain (C16), forms stable hydrogel nanoparticles by self-assembling in water. Hydrophobic chains, distributed along the polymer backbone, promote the formation of hydrophobic microdomains within the nanoparticles. The influence of degree of substitution with hydrophobic chains (DSC16) on nanoparticles size, colloidal stability, density, aggregation number and nanoparticle weight was studied. Size distribution was also evaluated at different pH, urea concentration and ionic strength conditions. As shown by dynamic light scattering and transmission electron microscopy, the particles are spherical having a diameter of about 20 nm. The more substituted polymer forms more densely packed hydrophobic microdomains, such that the colloidal stability (in water and PBS buffer) of nanoparticles is increased. The knowledge of the aggregate building process and the characteristics of the nanoparticles are crucial for the design of drug delivery systems.
TypeArticle
URIhttp://hdl.handle.net/1822/8357
DOI10.1016/j.eurpolymj.2008.08.034
ISSN0014-3057
Publisher versionwww.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TWW-4TC350R-4&_user=2459786&_coverDate=11%2F30%2F2008&_rdoc=18&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235573%232008%23999559988%23701105%23FLA%23display%23Volume)&_cdi=5573&_sort=d&_docanchor=&_ct=63&_acct=C000057396&_version=1&_urlVersion=0&_userid=2459786&md5=38db3828fab063dcd34330948926147a
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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