Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/73986

TitleInnovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application
Author(s)Carvalho, Duarte Nuno
Gonçalves, C.
Oliveira, J. M.
Willliams, D.
Mearns Spragg, A.
Reis, R. L.
Silva, Tiago H.
KeywordsCartilage tissue engineering
Gel strength
Marine biomaterials
Marine origin biopolymers
Mechanical Properties
Issue dateAug-2021
PublisherRoyal Society of Chemistry
JournalGreen Chemistry
CitationCarvalho D. N., Gonçalves C., Oliveira J. M., Willliams D., Mearns Spragg A., Reis R. L., Silva T. H. Innovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application, Green Chemistry, pp. 1-14, doi:10.1039/D1GC02223G, 2021
Abstract(s)Marine polymers such as collagen, chitosan, and fucoidan can be combined to form ionic-linked hydrogel networks towards applications in tissue engineering (TE). The use of greener approaches (as determined by green metrics â E-factor), including the absence of external chemical cross-linking agents, has advantages regarding the potential cytotoxicity. By tailoring the formulation of such an ionic-linked hydrogel, it is possible to fine-tune scaffold biofunctionality. In this study, a comparative study of composite hydrogels was accomplished, seeking to understand the correlation between polymer characteristics and physical behaviour to develop the applicability of this technology in soft-to-hard TE. Parameters such as polymer concentration, molecular weight, polymer-biomaterials bonds, biomaterial structural architecture, pore size, and mechanical rheological properties were directly correlated to the hydrogelâ s formulation. The results highlight that the formulation with greatest potential was the 3-component hydrogel (H12, followed by H10, H11), due to its superior mechanical properties, making it suitable for cartilage TE. This research offers a valuable perspective on hydrogel formulation and a new processing methodology, as well as how tailoring the hydrogel composition influences mechanical behaviour to support selecting the best composition for tissue engineering applications.
TypeArticle
DescriptionAccepted Manuscript
URIhttp://hdl.handle.net/1822/73986
DOI10.1039/D1GC02223G
ISSN1463-9270
Publisher versionhttps://pubs.rsc.org/en/content/articlelanding/2021/gc/d1gc02223g
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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