Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73867
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Inês G. | por |
dc.contributor.author | Simões, Lúcia Chaves | por |
dc.contributor.author | Simões, Manuel Lopes | por |
dc.date.accessioned | 2021-09-02T15:08:45Z | - |
dc.date.available | 2021-09-02T15:08:45Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | Gonçalves, Inês G.; Simões, Lúcia C.; Simões, Manuel, Legionella pneumophila. Trends in Microbiology, 29(9), 860-861, 2021 | por |
dc.identifier.issn | 0966-842X | por |
dc.identifier.uri | https://hdl.handle.net/1822/73867 | - |
dc.description.abstract | Legionella pneumophila is an intracellular pathogen, ubiquitous in the environment and considered opportunistic. It is the leading cause of legionellosis, which can be present in its nonpneumonic form (Pontiac fever) and acute pneumonic form (Legionnaires` disease – LD). In the soil and aquatic systems, L. pneumophila can invade and survive intracellularly in various protozoans. The ability to proliferate within biofilms provides additional protection from environmental stresses, such as disinfection. Human infection by L. pneumophila occurs after the inhalation or aspiration of aerosols containing the pathogen. Upon infection, alveolar macrophages can be invaded and used by L. pneumophila for replication, resembling the infection of protozoan hosts in the environment. The ability of L. pneumophila to overcome the killing mechanisms of phagocytes depends on the Dot/Icm type IV secretion system – a specialized protein translocation system vital for the intracellular survival of the pathogen and for establishing a replicative niche known as the Legionella-containing vacuole. Following host cell lysis, the released bacteria infect other host cells, beginning a new cycle of infection. | por |
dc.description.sponsorship | This work was financially supported by Base Funding – UIDB/00511/2020 of LEPABE and funded by national funds through the FCT/MCTES (PIDDAC); Project Biocide_for_Biofilm – PTDC/BII-BTI/30219/2017 – POCI-01-0145-FEDER-030219, pBio4.0 – POCI-01-0247-FEDER-033298, funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES; Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE 01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional do Norte. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | UIDB/00511/2020 | por |
dc.relation | PTDC/BII-BTI/30219/2017 | por |
dc.rights | openAccess | por |
dc.subject | Legionella | por |
dc.subject | Pneumophila | por |
dc.title | Legionella pneumophila | por |
dc.type | journalEditorial | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.cell.com/trends/microbiology/fulltext/S0966-842X(21)00113-X | por |
dc.comments | CEB54457 | por |
oaire.citationStartPage | 860 | por |
oaire.citationEndPage | 861 | por |
oaire.citationIssue | 9 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 29 | por |
dc.date.updated | 2021-08-30T16:19:48Z | - |
dc.identifier.doi | 10.1016/j.tim.2021.04.005 | por |
dc.identifier.pmid | 33994277 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Trends in Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54457_1.pdf | 699,09 kB | Adobe PDF | Ver/Abrir |