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https://hdl.handle.net/1822/72754
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Campo DC | Valor | Idioma |
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dc.contributor.author | Correia, Carla | por |
dc.contributor.author | Leite, Cláudia | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Carvalho, M. Alice | por |
dc.date.accessioned | 2021-05-20T15:14:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0960-894X | por |
dc.identifier.uri | https://hdl.handle.net/1822/72754 | - |
dc.description.abstract | Novel hydroxylated benzylideneamino imidazole derivatives were synthesized and their radical scavenging activity was assessed against DPPH and hydroxyl radicals. In the DPPH assay, most of the synthesized compounds showed an IC50 in the range 3.2 mu M <= IC50 <= 8.4 mu M, lower than the reference compound trolox (IC50 = 9.5 mu M) or the parent aldehydes (5.4 mu M <= IC50 <= 11.6 mu M). The activity depends mainly on the phenolic subunit (number and position of the hydroxyl groups) and the extent of conjugation with the imidazole ring. In the deoxyribose assay, all the compounds, including parent imidazoles and aldehydes, showed high activity against the hydroxyl radical and the ability to chelate iron ions. At 5 mu M concentration, the compounds protected the deoxyribose from degradation by hydroxyl radical between 62% and 38%. (C) 2014 Elsevier Ltd. All rights reserved. | por |
dc.description.sponsorship | The authors gratefully acknowledge the financial support to Universidade do Minho, Centro de Quimica and Fundacao para a Ciencia e Tecnologia (project nF-COMP-01-0124-FEDER-022716 (Ref. FCT PEst-/QUI/UI0686/2011) FEDER-COMPETE, FCT-Portugal, a PhD Grant awarded to C. Correia (SFRH/BD/22270/2005) and support to the NMR spectrometer (Bruker 400 Avance III) that is part of the National NMR Network. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | PEst-/QUI/UI0686/2011 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F22270%2F2005/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Radical scavengers | por |
dc.subject | DPPH radical | por |
dc.subject | Deoxyribose assay | por |
dc.subject | Phenol-imidazole conjugates | por |
dc.title | Synthesis and radical scavenging activity of phenol–imidazole conjugates | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0960894X1400362X | por |
oaire.citationStartPage | 2768 | por |
oaire.citationEndPage | 2772 | por |
oaire.citationIssue | 12 | por |
oaire.citationVolume | 24 | por |
dc.date.updated | 2021-05-19T11:09:23Z | - |
dc.identifier.eissn | 1464-3405 | por |
dc.identifier.doi | 10.1016/j.bmcl.2014.04.026 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 24803365 | - |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 10709 | - |
sdum.journal | Bioorganic & Medicinal Chemistry Letters | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2014BioorgMedChemLett2768.pdf Acesso restrito! | 430,69 kB | Adobe PDF | Ver/Abrir |