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TitleEmerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
Author(s)Soto, Fernando
Guimarães, Carlos F.
Reis, R. L.
Franco, Walfre
Rizvi, Imran
Demirci, Utkan
Externally driven assembly
Organ on a chip
Personalized medicine
Issue dateApr-2021
JournalCancer Letters
CitationSoto F., Guimarães C. F., Reis R. L., Franco W., Rizvi I., Demirci U. Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models, Cancer Letters, Vol. 504, pp. 116-124, doi:10.1016/j.canlet.2021.01.023, 2021
Abstract(s)Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.
Publisher version
AccessEmbargoed access (2 Years)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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