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TitleSynthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
Author(s)Teixeira, Jean Valdir Uchôa
Maia, F. Raquel
Carvalho, Mariana R.
Reis, R. L.
Oliveira, J. M.
Lisboa-Filho, Paulo Noronha
Claro, Ana Paula Rosifni Alves
Gallium incorporation
Nanoparticle synthesis
Issue dateJan-2021
PublisherFuture Medicine
CitationTeixeira J. V. U., Maia F. R., Carvalho M. R., Reis R. L., Oliveira J. M., Lisboa-Filho P. N., Claro A. P. R. A. Synthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications, Nanomedicine, doi:10.2217/nnm-2020-0312, 2021
Abstract(s)Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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