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TitlePAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis
Author(s)Oliveira, Isabel Maria Lopes Matos
Gonçalves, Cristiana
Oliveira, Maria Eduarda Moreira Pinheiro Santos
Simón-Váz, Rosana
da Silva Morais, Alain
González-Fernández, África
Reis, R. L.
Oliveira, J. M.
KeywordsRheumatoid arthritis
Inflamed joint
PAMAM dendrimer
Chondroitin sulphate
Anti-TNF α
Polyclonal antibody
Issue dateJan-2021
JournalMaterials Science and Engineering: C
CitationOliveira I. M., Cristiana G., Oliveira E. P., Rosana S. - V., Silva A. M., África G. - F., Reis R. L., Oliveira J. M. PAMAM Dendrimers Functionalised with an Anti-TNF α Antibody and Chondroitin Sulphate for Treatment of Rheumatoid Arthritis, Materials Science and Engineering: C, pp. 111845, doi:10.1016/j.msec.2020.111845, 2021
Abstract(s)Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein we aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF α antibodies (Abs) to provide anti-inflammatory properties. Physicochemical characterisation demonstrated that anti-TNFα Abs-CS/PAMAM dendrimer NPs were successfully produced. The in vitro studies revealed that CS/PAMAM dendrimer NPs did not affect the ATDC5 and THP-1 cell lines' metabolic activity and proliferation, presenting good cytocompatibility and hemocompatibility. Moreover, anti-TNFα Abs-CS/PAMAM dendrimer NPs showed suitable TNF α capture capacity, making them appealing for new immunotherapies in RA patients.
Description"Available online 6 January 2021"
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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