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TitleImpact of citrate and lipid-functionalized magnetic nanoparticles in dehydropeptide supramolecular magnetogels: properties, design and drug release
Author(s)Veloso, Sérgio R S
Silva, Joana F G
Hilliou, L.
Moura, Cacilda
Coutinho, Paulo J. G.
Martins, J. A. R.
Testa-Anta, Martín
Salgueiriño, Verónica
Correa-Duarte, Miguel A
Ferreira, Paula M. T.
Castanheira, Elisabete M. S.
Keywordsmagnetic nanoparticles
drug delivery
Issue dateDec-2020
CitationVeloso, S.R.S.; Silva, J.F.G.; Hilliou, L.; Moura, C.; Coutinho, P.J.G.; Martins, J.A.; Testa-Anta, M.; Salgueiriño, V.; Correa-Duarte, M.A.; Ferreira, P.M.T.; Castanheira, E.M.S. Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release. Nanomaterials 2021, 11, 16.
Abstract(s)Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels' self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications.
Publisher version
AccessOpen access
CDQuim - Artigos (Papers)
IPC - Artigos em revistas científicas internacionais com arbitragem

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