Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68243
Título: | Estrogens, MSI and Lynch syndrome-associated tumors |
Autor(es): | Ferreira, Ana Monteiro Westers, Helga Albergaria, André Seruca, Raquel Hofstra, Robert M W |
Palavras-chave: | Animals Colonic Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis DNA Mismatch Repair Endometrial Neoplasms Estrogens Female Humans Receptors, Estrogen Microsatellite Instability Estrogen Estrogen-receptor pathway Lynch syndrome Mismatch repair system |
Data: | Dez-2009 |
Editora: | Elsevier Science BV |
Revista: | Biochimica et Biophysica Acta (BBA). Reviews on Cancer |
Resumo(s): | Estrogens play a major role in the biology of hormone-responsive tissues but also in the normal physiology of various non-typical hormone-responsive tissues. In disease, estrogens have been associated with tumor development, in particular with tumors such as breast, endometrium, ovary and prostate. In this paper we will review the molecular mechanisms by which estrogens are involved in cancer development, with a special focus in Lynch syndrome related neoplasia. Further, we discuss the role estrogens might have on cell proliferation and apoptosis, how estrogens metabolites can induce DNA damage and we discuss a possible connection between estrogens and changes in DNA (hypo- and hyper) methylation. In this review we will also address the protective effect that high levels of estrogens have in MMR related neoplasias. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/68243 |
DOI: | 10.1016/j.bbcan.2009.06.004 |
ISSN: | 0304-419X |
Versão da editora: | https://www.sciencedirect.com/science/article/abs/pii/S0304419X0900033X |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Ferreira-2009-Estrogens-msi-and-lynch-syndrome-as.pdf Acesso restrito! | 575,86 kB | Adobe PDF | Ver/Abrir |