Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/67651

TitleImmunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort
Author(s)Syrjänen, Stina
Naud, Paulo
Sarian, Luis
Derchain, Sophie
Roteli-Martins, Cecilia
Longatto, Adhemar
Tatti, Silvio
Branca, Margherita
Erzen, Mojca
Hammes, L. S.
Costa, S.
Syrjänen, Kari
KeywordsAdult
Cervical Intraepithelial Neoplasia
Cohort Studies
DNA, Viral
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Interleukin-10
Papillomavirus Infections
Prospective Studies
Up-Regulation
Uterine Cervical Neoplasms
Vaginal Smears
High-risk HPV
Immunosuppressive cytokines
Th cells
CIN
Viral outcomes
Disease progression
Longitudinal predictive values
Surrogate endpoints
Issue dateDec-2009
PublisherSpringer
JournalVirchows Archiv
CitationSyrjänen, S., Naud, P., Sarian, L., Derchain, S., et. al. (2009). Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort. Virchows Archiv, 455(6), 505-515
Abstract(s)Bypassing the local immunological defense reactions in the cervix is one of the prerequisites for human papillomaviruses (HPV) infections to progress to intraepithelial neoplasia (CIN). The role of potent immunosuppressive cytokines, e.g., interleukin-10 (IL-10), depressing these local virus-specific immunological responses is incompletely studied. To assess, whether IL-10 expression in cervical HPV lesions has any implications in the outcome of HPV infections or disease progression to CIN. Baseline cervical biopsies from 225 women of the LAMS study sub-cohort were analyzed for IL-10 expression using immunohistochemistry, to assess its associations with CIN grade, and high-risk HPV (HR-HPV) at baseline, as well as in predicting outcomes of HR-HPV infections, and development of incident CIN1+ and CIN2+ in this longitudinal setting. Expression of IL-10 in cervical lesions was up-regulated most often in high-grade CIN, and IL-10 over-expression retained its value as independent predictor of CIN2+ (odds ratio (OR) = 4.92) and CIN3+ (OR = 7.51) also in multivariate model, including HR-HPV and several known covariates of IL-10 expression. Up-regulation was not related to HR-HPV detection, and showed no relationship to HR-HPV viral loads. Using longitudinal predictive indicators (SE, SP, PPV, NPV), IL-10 expression was of no value in predicting (1) the outcomes of HR-HPV infections, or (2) the surrogate endpoints (incident CIN1+, CIN2+) of progressive disease. IL-10 over-expression (along with HR-HPV) was one of the independent covariates of CIN2/3. This immunosuppressive cytokine might play an important role in creating a microenvironment that favors progressive cervical disease and immune evasion by HR-HPV.
TypeArticle
URIhttps://hdl.handle.net/1822/67651
DOI10.1007/s00428-009-0850-7
ISSN0945-6317
e-ISSN1432-2307
Publisher versionhttps://link.springer.com/article/10.1007/s00428-009-0850-7
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

Files in This Item:
File Description SizeFormat 
Syrjanen-2009-Immunosuppressive-cytokine-interleu.pdf
  Restricted access
361,85 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID