Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/67567

TitleUp-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study
Author(s)Syrjänen, Stina
Naud, Paulo
Sarian, Luis
Derchain, Sophie
Roteli-Martins, Cecilia
Longatto, Adhemar
Tatti, Silvio
Branca, Margerita
Erzen, Mojca
Hammes, Luciano S
Costa, Silvano
Syrjänen, Kari
Keywords14-3-3 Proteins
Alphapapillomavirus
Biomarkers, Tumor
Biopsy
Cervical Intraepithelial Neoplasia
Exonucleases
Exoribonucleases
Female
Humans
Multicenter Studies as Topic
Neoplasm Proteins
Papillomavirus Infections
Treatment Outcome
Up-Regulation
High-risk human papillomavirus
Stratifin
14-3-3σ
Cell cycle control
Inactivation
Overexpression
Epigenetic
Viral outcomes
Disease progression
Longitudinal predictive values
Surrogate end points
14-3-3 sigma
Issue dateFeb-2010
PublisherOxford University Press
JournalAmerican Journal of Clinical Pathology
Abstract(s)To assess whether the potentially high-risk (HR) human papillomavirus (HPV)-related up-regulation of 14-3-3sigma (stratifin) has implications in the outcome of HPV infections or cervical intraepithelial neoplasia (CIN) lesions, cervical biopsy specimens from 225 women in the Latin American Screening Study were analyzed for 14-3-3sigma expression using immunohistochemical analysis. We assessed its associations with CIN grade and HR HPV at baseline and value in predicting outcomes of HR-HPV infections and the development of incident CIN 1+ and CIN 2+. Expression of 14-3-3sigma increased in parallel with the lesion grade. Up-regulation was also significantly related to HR-HPV detection (P = .004; odds ratio, 2.71; 95% confidence interval, 1.37-5.35) and showed a linear relationship to HR-HPV loads (P = .003). 14-3-3sigma expression was of no value in predicting the outcomes (incident, persistent, clearance) of HR-HPV infections or incident CIN 1+ and CIN 2+. 14-3-3sigma is not inactivated in cervical carcinoma and CIN but is up-regulated on transition from CIN 2 to CIN 3. Its normal functions in controlling G(1)/S and G(2)/M checkpoints are being bypassed by HR HPV.
TypeArticle
URIhttps://hdl.handle.net/1822/67567
DOI10.1309/AJCP49DOITYDCTQJ
ISSN1943-7722
e-ISSN0002-9173
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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