Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/66987

TitleAromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse
Author(s)Brito, Alexandra Manuela Fernandes
Pereira, P. M. R.
Reis, R. L.
Ulijn, R. V.
Lewis, J. S.
Pires, R. A.
Pashkuleva, I.
Keywords3D cancer models
Biocatalytic self-assembly
Chemotherapy
GLUT1
Glycolysis
Issue dateSep-2020
PublisherRoyal Society of Chemistry
JournalNanoscale
CitationBrito A., Pereira P. M. R., Reis R. L., Ulijn R. V., Lewis J. S., Pires R. A., Pashkuleva I. Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse, Nanoscale, Vol. 12, doi:10.1039/D0NR05008C, 2020
Abstract(s)Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse.
TypeArticle
DescriptionAccepted Manuscript
URIhttp://hdl.handle.net/1822/66987
DOI10.1039/D0NR05008C
ISSN2040-3364
e-ISSN2040-3372
Publisher versionhttps://pubs.rsc.org/en/Content/ArticleLanding/2020/NR/D0NR05008C#!divAbstract
Peer-Reviewedyes
AccessEmbargoed access (1 Year)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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