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TitleAromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse
Author(s)Brito, Alexandra Manuela Fernandes
Pereira, P. M. R.
Reis, R. L.
Ulijn, R. V.
Lewis, J. S.
Pires, R. A.
Pashkuleva, I.
Keywords3D cancer models
Biocatalytic self-assembly
Issue dateSep-2020
PublisherRoyal Society of Chemistry
CitationBrito A., Pereira P. M. R., Reis R. L., Ulijn R. V., Lewis J. S., Pires R. A., Pashkuleva I. Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse, Nanoscale, Vol. 12, doi:10.1039/D0NR05008C, 2020
Abstract(s)Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse.
DescriptionAccepted Manuscript
Publisher version!divAbstract
AccessEmbargoed access (1 Year)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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