Please use this identifier to cite or link to this item:
|Title:||Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine|
|Author(s):||Casanova, Marta Alexandra Rodrigues|
Reis, R. L.
Neves, N. M.
Tissue engineering and regenerative medicine
|Publisher:||Royal Society of Chemistry|
|Citation:||Casanova M. R., Reis R. L., Martins A., Neves N. M. Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine, Materials Horizons, pp. 1-18, doi:10.1039/D0MH00542H, 2020|
|Abstract(s):||Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade, mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, as well as the most relevant results achieved in the novel and most promising strategies.|
|Access:||Restricted access (UMinho)|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
Files in This Item:
|1,42 MB||Adobe PDF||View/Open|