Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/66345

TitleInhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1
Author(s)Brito, Alexandra
Pereira, Patrícia M.
Costa, Diana Soares da
Reis, R. L.
Ulijn, Rein V.
Lewis, Rein V.
Pires, R. A.
Pashkuleva, I.
KeywordsApoptosis
Biocatalytic self-assembly
GLUT inhibitor
Osteosarcoma
Warburg effect
Issue date2020
PublisherRoyal Society of Chemistry
JournalChemical Science
CitationBrito A., Pereira P. M. R., Soares da Costa D., Reis R. L., Ulijn R. V., Lewis J. S., Pires R. A., Pashkuleva I. Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1, Chemical Science, Vol. 11, Issue 14, pp. 3737-3744, doi:10.1039/D0SC00954G, 2020
Abstract(s)We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer associated GLUT1 and alkaline phosphatase are crucial for the effectiveness of this combined approach: cancer cells that overexpress both proteins are prompter to cell death when compared to GLUT1 overexpressing cells. Overall, we showcase that the synergism between physical and biochemical deprivation of cancer metabolism is a powerful approach for development of effective anticancer therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/66345
DOI10.1039/D0SC00954G
ISSN2041-6539
Publisher versionhttps://doi.org/10.1039/D0SC00954G
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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