Please use this identifier to cite or link to this item:

TitleInhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1
Author(s)Brito, Alexandra
Pereira, Patrícia M.
Costa, Diana Soares da
Reis, R. L.
Ulijn, Rein V.
Lewis, Rein V.
Pires, R. A.
Pashkuleva, I.
Biocatalytic self-assembly
GLUT inhibitor
Warburg effect
Issue date2020
PublisherRoyal Society of Chemistry
JournalChemical Science
CitationBrito A., Pereira P. M. R., Soares da Costa D., Reis R. L., Ulijn R. V., Lewis J. S., Pires R. A., Pashkuleva I. Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1, Chemical Science, Vol. 11, Issue 14, pp. 3737-3744, doi:10.1039/D0SC00954G, 2020
Abstract(s)We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer associated GLUT1 and alkaline phosphatase are crucial for the effectiveness of this combined approach: cancer cells that overexpress both proteins are prompter to cell death when compared to GLUT1 overexpressing cells. Overall, we showcase that the synergism between physical and biochemical deprivation of cancer metabolism is a powerful approach for development of effective anticancer therapies.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
20271-Brito_ChemSci_2020.pdf11,43 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID