Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/66192

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dc.contributor.authorLima, Ruipor
dc.contributor.authorMonteiro, Susanapor
dc.contributor.authorGomes, Eduardo Domingos Correiapor
dc.contributor.authorVasconcelos, Natália L.por
dc.contributor.authorAssunção-Silva, Ritapor
dc.contributor.authorMorais, Mónicapor
dc.contributor.authorSalgado, A. J.por
dc.contributor.authorSilva, Nuno André Martinspor
dc.date.accessioned2020-07-30T14:27:19Z-
dc.date.available2020-07-30T14:27:19Z-
dc.date.issued2020-
dc.identifier.citationLima, R.; Monteiro, S.; Gomes, E.D.; Vasconcelos, N.L.; Assunção-Silva, R.; Morais, M.; Salgado, A.J.; Silva, N.A. Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury. Int. J. Mol. Sci. 2020, 21, 5062.por
dc.identifier.urihttp://hdl.handle.net/1822/66192-
dc.description.abstractCitalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI.por
dc.description.sponsorshipThis research was funded by Prémios Santa Casa Neurociências—Prize Melo e Castro for SpinalCord Injury Research, Grant Number MC-04/17 and the Portuguese Foundation for Science and Technology(FCT) through the Scientific Employment Stimulus to N. Silva and S. Monteiro (CEECIND/04794/2017 and CEECIND/01902/2017) and fellowships to RL (PD/BDE/127836/2016); EDG (SFRH/BD/103075/2014);NLV (SFRH/BD/136952/2018) and R.AS (PDE/BDE/113596/2015).This work was also funded by FEDER,through the Competitiveness Internalization Operational Program (POCI) and by National funds, throughthe Foundation for Sciences and Technology (FCT), under the scope of the projects POCI-01-0145-FEDER-007038,POCI-01-0145-FEDER-029206, POCI-01-0145-FEDER-029751 and PTDC/BTM-MAT/29968/2017. This work hasbeen funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI - PortuguesePlatform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122; by National funds, through the Foundationfor Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020; and by the projectsNORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Program (NORTE2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).por
dc.language.isoengpor
dc.publisherMultidisciplinary Digital Publishing Institutepor
dc.relationCEECIND/04794/2017por
dc.relationCEECIND/01902/2017por
dc.relationPD/BDE/127836/2016por
dc.relationSFRH/BD/103075/2014por
dc.relationSFRH/BD/136952/2018por
dc.relationPDE/BDE/113596/2015por
dc.relationPTDC/BTM-MAT/29968/2017por
dc.relationUIDB/50026/2020por
dc.relationUIDP/50026/2020por
dc.rightsopenAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/por
dc.subjectspinal cord injurypor
dc.subjectcitaloprampor
dc.subjectSSRIpor
dc.subjectmotor recoverypor
dc.subject5-HTpor
dc.titleCitalopram administration does not promote function or histological recovery after spinal cord injurypor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/21/14/5062por
dc.date.updated2020-07-24T13:37:45Z-
dc.identifier.essn1422-0067-
dc.identifier.doi10.3390/ijms21145062por
sdum.journalInternational Journal of Molecular Sciencespor
oaire.versionVoRpor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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