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dc.contributor.authorMartins, Tiago D.por
dc.contributor.authorLima, Euricopor
dc.contributor.authorBoto, Renato E.por
dc.contributor.authorFerreira, Diana Sara Pereirapor
dc.contributor.authorFernandes, José R.por
dc.contributor.authorAlmeida, Paulopor
dc.contributor.authorFerreira, Luis F. V.por
dc.contributor.authorSilva, Amélia M.por
dc.contributor.authorReis, Lucinda V.por
dc.description.abstractPhotodynamic therapy is a medical modality developed for the treatment of several diseases of oncological and non-oncological etiology that requires the presence of a photosensitizer, light and molecular oxygen, which combined will trigger physicochemical reactions responsible for reactive oxygen species production. Given the scarcity of photosensitizers that exhibit desirable characteristics for its potential application in this therapeutic strategy, the main aims of this work were the study of the photophysical and photochemical properties and the photobiological activity of several dicyanomethylene squaraine cyanine dyes. Thus, herein, the study of their aggregation character, photobleaching and singlet oxygen production ability, and the further application of the previously synthesized dyes in Caco-2 and HepG2 cancer cell lines, to evaluate their phototherapeutic effects, are described. Dicyanomethylene squaraine dyes exhibited moderate light-stability and, despite the low singlet oxygen quantum yields, were a core of dyes that exhibited relevant <i>in vitro</i> photodynamic activity, as there was an evident increase in the toxicity of some of the tested dyes exclusive to radiation treatments.por
dc.description.sponsorshipThis research was funded by the European Investment Funds by FEDER/COMPETE/POCI under projects POCI-01-0145-FEDER-006958 (CITAB) and POCI-01-0145-FEDER-007491 (CICS-UBI) and Funds by FCT – Portuguese Foundation for Science and technology, under the projects UIDB/04033/2019 (CITAB) and UIDB/00616/2020 (CQ-VR). This work was also supported by funds from the Health Sciences Research Center (CICS-UBI) through National Funds by FCT—Foundation for Science and Technology (UID/Multi/00709/2019). The research at CQFM was supported by Project UID/NAN/50024/2019 and M-ERA-NET/0002/2015 from FCT. E. L. was supported by the FCT PhD grant SFRH/BD/147645/2019.por
dc.publisherMultidisciplinary Digital Publishing Institutepor
dc.subjectdicyanomethylene squaraine dyespor
dc.subjectsinglet oxygenpor
dc.subjectantiproliferative effectspor
dc.subjectphotodynamic therapypor
dc.titleRed and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: photophysicochemical properties and anti-tumor photosensitizing effectspor
dc.subject.fosEngenharia e Tecnologia::Engenharia dos Materiaispor
Appears in Collections:DET/2C2T - Artigos em revistas internacionais com arbitragem científica

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