Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64862

TitleDesigning microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions
Author(s)Tsiapalis, D.
Ribeiro, S.
De Pieri, A.
Sallent, I.
Guillaumin, S.
Gaspar, D.
Korntner, S.
Bayon, Y.
Gomes, Manuela E.
Reis, R. L.
Zeugolis, D. I.
KeywordsMicroenvironmental cues
Surface topography
Tissue engineering
Bone marrow mesenchymal stem cells
Coculture systems
Low oxygen tension
Mechanical loading
Substrate stiffness
Issue dateJun-2019
PublisherAcademic Press
CitationTsiapalis D., Ribeiro S., De Pieri A., Sallent I., Guillaumin S., Gaspar D., Korntner S., Bayon Y., Gomes M. E., Reis R. L., Zeugolis D. I. Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions, Encyclopedia of Tissue Engineering and Regenerative Medicine, pp. 119-30, 9780128136997, 2019
Abstract(s)Bone marrow mesenchymal stem cells have been extensively used for tissue engineering and regenerative medicine applications due to their ease of isolation and expansion and their ability to differentiate towards various lineages of mesodermal origin. Despite these properties, their clinical potential is often hampered by the simplicity of the in vitro environment and its inability to resemble the complex in vivo niche. Herein, different microenvironmental cues (e.g. surface topography, substrate stiffness, mechanical stimulation, oxygen tension and co-culture systems) that have been utilised to enhance the therapeutic efficacy of bone marrow mesenchymal stem cells are discussed.
TypeBook part
URIhttp://hdl.handle.net/1822/64862
ISBN9780128136997
DOI10.1016/B978-0-12-801238-3.11140-7
Publisher versionhttps://www.elsevier.com/books/encyclopedia-of-tissue-engineering-and-regenerative-medicine/reis/978-0-12-813699-7
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters


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