Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64839

TitleMultifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface
Author(s)Silva, E. D.
Babo, Pedro Miguel Sousa
Costa-Almeida, R.
Domingues, R. M. A.
Mendes, B. B.
Paz, E.
Freitas, P.
Rodrigues, M. T.
Granja, P. L.
Gomes, Manuela E.
Keywordsco-culture system
functionalized SPIONs
Magnetic responsive hydrogels
Platelet lysate
tendon-to-bone interface
Issue dateOct-2018
PublisherElsevier
JournalNanomedicine: Nanotechnology, Biology and Medicine
CitationSilva E. D., Babo P. S., Costa-Almeida R., Domingues R. M. A., Mendes B. B., Paz E., Freitas P., Rodrigues M. T., Granja P. L., Gomes M. E. Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 14, Issue 7, pp. 2375-2385, doi:10.1016/j.nano.2017.06.002, 2018
Abstract(s)Photocrosslinkable magnetic hydrogels are attracting great interest for tissue engineering strategies due to their versatility and multifunctionality, including their remote controllability ex vivo, thus enabling engineering complex tissue interfaces. This study reports the development of a photocrosslinkable magnetic responsive hydrogel made of methacrylated chondroitin sulfate (MA-CS) enriched with platelet lysate (PL) with tunable features, envisioning their application in tendon-to-bone interface. MA-CS coated iron-based magnetic nanoparticles were incorporated to provide magnetic responsiveness to the hydrogel. Osteogenically differentiated adipose-derived stem cells and/or tendon-derived cells were encapsulated within the hydrogel, proliferating and expressing bone- and tendon-related markers. External magnetic field (EMF) application modulated the swelling, degradation and release of PL-derived growth factors, and impacted both cell morphology and the expression and synthesis of tendon- and bone-like matrix with a more evident effect in co-cultures. Overall, the developed magnetic responsive hydrogel represents a potential cell carrier system for interfacial tissue engineering with EMF-controlled properties.
TypeArticle
URIhttp://hdl.handle.net/1822/64839
DOI10.1016/j.nano.2017.06.002
ISSN1549-9634
Publisher versionhttp://www.nanomedjournal.com/article/S1549-9634(17)30108-9/abstract
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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