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dc.contributor.authorMoreira, Joanapor
dc.contributor.authorVale, A. Catarinapor
dc.contributor.authorPires, R. A.por
dc.contributor.authorBotelho, Gabrielapor
dc.contributor.authorReis, R. L.por
dc.contributor.authorAlves, N. M.por
dc.identifier.citationMoreira, J.; Vale, A.C.; A. Pires, R.; Botelho, G.; Reis, R.L.; Alves, N.M. Spin-Coated Polysaccharide-Based Multilayered Freestanding Films with Adhesive and Bioactive Moieties. Molecules 2020, 25, 840.por
dc.description.abstractFreestanding films based on catechol functionalized chitosan (CHI), hyaluronic acid (HA), and bioglass nanoparticles (BGNPs) were developed by spin-coating layer-by-layer assembly (SA-LbL). The catechol groups of 3,4-dihydroxy-<span style="font-variant: small-caps;">l</span>-phenylalanine (DOPA) present in the marine mussels adhesive proteins (MAPs) are the main factors responsible for their characteristic strong wet adhesion. Then, the produced films were cross-linked with genipin to improve their stability in wet state. Overall, the incorporation of BGNPs resulted in thicker and bioactive films, hydrophilic and rougher surfaces, reduced swelling, higher weight loss, and lower stiffness. The incorporation of catechol groups onto the films showed a significant increase in the films’ adhesion and stiffness, lower swelling, and weight loss. Interestingly, a synergetic effect on the stiffness increase was observed upon the combined incorporation of BGNPs with catechol-modified polymers, given that such films were the stiffest. Regarding the biological assays, the films exhibited no negative effects on cellular viability, adhesion, and proliferation, and the BGNPs seemed to promote higher cellular metabolic activity. These bioactive LbL freestanding films combine enhanced adhesion with improved mechanical properties and could find applications in the biomedical field, such as guided hard tissue regeneration membranes.por
dc.description.sponsorshipThis research was funded by the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/FEEI (PTDC/BTM-MAT/28123/2017 and PTDC/NAN-MAT/31036/2017) and FCT (MIT-EXPL/BIO/0089/2017).por
dc.description.sponsorshipThe authors acknowledge the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/FEEI for the financial support through projects PTDC/BTM-MAT/28123/2017 and PTDC/NAN-MAT/31036/2017. The authors also acknowledge FCT for the financial support through the exploratory project MIT-EXPL/BIO/0089/2017.por
dc.publisherMultidisciplinary Digital Publishing Institutepor
dc.subjectfreestanding filmspor
dc.subjectcatechol-modified polymerspor
dc.titleSpin-coated polysaccharide-based multilayered freestanding films with adhesive and bioactive moietiespor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
CDQuim - Artigos (Papers)

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