Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64577

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dc.contributor.authorPereira, Carlapor
dc.contributor.authorCalhelha, Ricardo C.por
dc.contributor.authorAntonio, Amilcar L.por
dc.contributor.authorQueiroz, Maria João R. P.por
dc.contributor.authorBarros, Lillianpor
dc.contributor.authorFerreira, Isabel C.F.R.por
dc.date.accessioned2020-03-25T15:59:39Z-
dc.date.available2020-03-25T15:59:39Z-
dc.date.issued2014-
dc.identifier.issn1466-8564por
dc.identifier.urihttp://hdl.handle.net/1822/64577-
dc.description.abstractBorututu is a well-known medicinal plant in Angola for the treatment of liver diseases and for the prophylaxis of malaria. Our research group reported, in a recent study, that its infusion, pills and syrups display significant antioxidant and anti-hepatocellular carcinoma activities. However, during the processing and storage, it can be easily exposed to contamination that can lead to a microbial deterioration or insect infestation compromising its quality, shelf life, and efficiency. Herein, we investigated the effect of gamma irradiation, one of the most promising decontamination methods for many foodstuffs and plant materials, at different doses (1 and 10 kGy) on borututu regarding its nutritional value, lipophilic (fatty acids and tocopherols) and hydrophilic (free sugars and organic acids) compounds, antioxidant and anti-hepatocellular carcinoma activities. In general, the irradiation treatment did not appreciably affect the nutritional value of the studied plant, but the highest energetic contribution (383.83 kcal/100 g), total sugars (8.63 g/100 g), organic acids (3.31 g/100 g dw), total tocopherols (336.72 mg/100 g dw), and PUFA (32.75%) contents were found in the sample irradiated at 10 kGy. Furthermore, this sample presented also the highest levels of total phenolics and flavonoids and, in general, the highest antioxidant activity (EC50 values of 0.04 to 0.24 mg/mL for the methanolic extract and 0.03 to 1.34 mg/mL for the infusion). Irradiated samples kept the anti-hepatocellular carcinoma activity, but a decrease was observed in the methanolic extract prepared from sample irradiated at 10 kGy (GI50 = 188.97 μg/mL). Overall, gamma irradiation proved to be a suitable technique of preservation of dried herbs without affecting the bioactive compounds.por
dc.language.isoengpor
dc.publisherElsevier Science Ltdpor
dc.rightsopenAccesspor
dc.titleEffects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututupor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1466856414000812por
dc.identifier.doi10.1016/j.ifset.2014.05.010por
sdum.journalInnovative Food Science & Emerging Technologiespor
oaire.versionAMpor
Appears in Collections:CDQuim - Artigos (Papers)

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