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dc.contributor.authorHeleno, Sandrina A.por
dc.contributor.authorFerreira, Isabel C. F. R.por
dc.contributor.authorĆirić, Anapor
dc.contributor.authorGlamočlija, Jasminapor
dc.contributor.authorMartins, Anabelapor
dc.contributor.authorQueiroz, Maria João R. P.por
dc.contributor.authorSoković, Marinapor
dc.description.abstractDespite the available data regarding antimicrobial activity of phenolic acids, studies dealing with the effects of their metabolites or derivatives are scarce. Therefore, the antimicrobial and demelanizing activities of Coprinopsis atramentaria extract, its organic acids, and methylated and glucuronated derivatives were evaluated. The antifungal activity was stronger than the antibacterial effects. In general, individual compounds (mostly organic acids) exhibited higher activity than the extract and even higher than the standards used in the assays. Methylated derivatives presented the highest demelanizing activity toward Aspergillus niger, A. fumigatus and Penicillium verrucosum var. cyclopium. The inclusion of methyl groups in the parental compound (CoAM1, CoAM2 and CoAM3) strongly increased antibacterial and antifungal activities of CoA, while the inclusion of acetyl groups (CoAGP) increased the antifungal activity but the antibacterial properties were maintained. For HA and CA, the inclusion of methyl groups (HAM1, HAM2, HAM3 and CAM) increased the demelanizing activity, but decreased the antimicrobial properties. The present work contributes to the knowledge of the mechanisms involved in the antimicrobial properties of organic acids namely, phenolic acids, usually present in mushrooms. Organic acids, and methylated and glucuronated derivatives could be used as antimicrobial agents.por
dc.description.sponsorshipThe authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for financial support to the Portuguese NMR network and to FCT and FEDER-COMPETE/QREN/EU for the financial support through the research project PTDC/AGR-ALI/110062/2009 and the research centres (PEst-C/QUI/UI0686/2011 and PEst-OE/AGR/UI0690/2011). S. A. Heleno (BD/70304/2010) also thanks FCT, POPH-QREN and FSE for her grant. The authors also thank Serbian Ministry of Education, Science and Technological development (grant number 173032) for financial support.por
dc.publisherRoyal Society of Chemistrypor
dc.titleCoprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agentspor
sdum.journalFood & Functionpor
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