Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/64315
Título: | Glucocorticoids and neuro- and behavioural development |
Autor(es): | Mesquita, Ana Raquel Marcelino Wegerich, Yvonne Patchev, Alexandre V. Oliveira, Mário Leão, Pedro Sousa, Nuno Almeida, Osborne F. X. |
Palavras-chave: | Adrenal cortex hormones Animals Brain Child development Female Fetus Humans Hypothalamo-Hypophyseal system Infant Pituitary-Adrenal system Pregnancy Prenatal exposure delayed effects Receptors, glucocorticoid Receptors, mineralocorticoid Stress, physiological Stress, psychological Anxiety Depression Glucocorticoid Postnatal Prenatal Neurodevelopment Stress |
Data: | Jun-2009 |
Editora: | Elsevier |
Revista: | Seminars in Fetal & Neonatal Medicine |
Resumo(s): | Epidemiological evidence links exposure to stress hormones during fetal or early postnatal development with lifetime prevalence of cardiac, metabolic, auto-immune, neurological and psychiatric disorders. This has led to the concept of 'developmental programming through stress'. Importantly, these effects (specifically, hypertension, hyperglycaemia and neurodevelopmental and behavioural abnormalities) can be reproduced by exposure to high glucocorticoid levels, indicating a crucial role of glucocorticoids in their causation. However, there can be important differences in outcome, depending on the exact time of exposure, as well as duration and receptor selectivity of the glucocorticoid applied. The mechanisms underlying programming by stress are still unclear but it appears that these environmental perturbations exploit epigenetic modifications of DNA and/or histones to induce stable modifications of gene expression. Programming of neuro- and behavioural development by glucocorticoids and stress are important determinants of lifetime health and should be a consideration when choosing treatments in obstetric and neonatal medicine. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/64315 |
DOI: | 10.1016/j.siny.2008.11.002 |
ISSN: | 1744-165X |
e-ISSN: | 1878-0946 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1744165X08001340#! |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Mesquita-2009-Glucocorticoids-and-neuro--and-beha.pdf Acesso restrito! | 162,86 kB | Adobe PDF | Ver/Abrir |