Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64315

TitleGlucocorticoids and neuro- and behavioural development
Author(s)Mesquita, Ana Raquel Marcelino
Wegerich, Yvonne
Patchev, Alexandre V.
Oliveira, Mário
Leão, Pedro
Sousa, Nuno
Almeida, Osborne F. X.
KeywordsAdrenal cortex hormones
Animals
Brain
Child development
Female
Fetus
Humans
Hypothalamo-Hypophyseal system
Infant
Pituitary-Adrenal system
Pregnancy
Prenatal exposure delayed effects
Receptors, glucocorticoid
Receptors, mineralocorticoid
Stress, physiological
Stress, psychological
Anxiety
Depression
Glucocorticoid
Postnatal
Prenatal
Neurodevelopment
Stress
Issue dateJun-2009
PublisherElsevier
JournalSeminars in Fetal & Neonatal Medicine
Abstract(s)Epidemiological evidence links exposure to stress hormones during fetal or early postnatal development with lifetime prevalence of cardiac, metabolic, auto-immune, neurological and psychiatric disorders. This has led to the concept of 'developmental programming through stress'. Importantly, these effects (specifically, hypertension, hyperglycaemia and neurodevelopmental and behavioural abnormalities) can be reproduced by exposure to high glucocorticoid levels, indicating a crucial role of glucocorticoids in their causation. However, there can be important differences in outcome, depending on the exact time of exposure, as well as duration and receptor selectivity of the glucocorticoid applied. The mechanisms underlying programming by stress are still unclear but it appears that these environmental perturbations exploit epigenetic modifications of DNA and/or histones to induce stable modifications of gene expression. Programming of neuro- and behavioural development by glucocorticoids and stress are important determinants of lifetime health and should be a consideration when choosing treatments in obstetric and neonatal medicine.
TypeArticle
URIhttp://hdl.handle.net/1822/64315
DOI10.1016/j.siny.2008.11.002
ISSN1744-165X
e-ISSN1878-0946
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S1744165X08001340#!
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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