Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64289

TitleInduction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids
Author(s)Oliveira, Mário Jorge Alves
Bessa, João M.
Mesquita, Ana
Tavares, Hugo Miguel Braga Almeida
Carvalho, André Filipe Couto
Silva, Rui
Pêgo, José M.
Cerqueira, João José
Palha, Joana Almeida
Almeida, Osborne F. X.
Sousa, Nuno
KeywordsAdrenal Cortex Hormones
Age Factors
Animals
Anxiety Disorders
Behavior, Animal
Birth Weight
Depression
Dexamethasone
Disease Models, Animal
Dose-Response Relationship, Drug
Exploratory Behavior
Female
Freezing Reaction, Cataleptic
Helplessness, Learned
Hypothalamo-Hypophyseal System
Male
Maternal Deprivation
Memory
Pituitary-Adrenal System
Pregnancy
Rats
Rats, Wistar
Sex Factors
Spatial Behavior
Prenatal Exposure Delayed Effects
Neurodevelopment
Corticosteroids
Antenatal corticotherapy
Anxiety
Depression
Cognition
Issue date1-May-2006
PublisherElsevier
JournalBiological Psychiatry
Abstract(s)Background: Synthetic glucocorticoids are commonly prescribed during pregnancy, despite a lack of systematic investigations of their potential impact on the developing brain and neurological and behavioral performance. Methods: Neuroendocrine parameters and behavior in the adult offspring of pregnant Wistar rats treated antenatally with either dexamethasone (DEX) or corticosterone (CORT) were monitored; DEX (.1 mg/kg and 1 mg/kg) and CORT (25 mg/kg) were given to pregnant rat dams on gestation days 18 and 19. Results: Despite normal basal levels of corticosterone, the adult offspring of mothers given DEX or CORT displayed abnormal responses in the dexamethasone-suppression test. Neither treatment influenced spatial memory performance, but both DEX and CORT facilitated development of depressionlike behavior following chronic stress. The latter finding demonstrates that high-dose antenatal corticotherapy can impair the organism’s resilience to stress in adulthood. Interestingly, comparison of the progeny of CORT-treated and DEX-treated mothers revealed that the latter were more anxious. Conclusions: Since DEX and CORT differ in their affinity for glucocorticoid and mineralocorticoid receptors and corticosteroidbinding globulin, our findings emphasize the need to consider the pharmacologic properties of antenatal corticotherapies and demonstrate the potential long-term benefits of ligands that can bind to both receptors.
TypeArticle
URIhttp://hdl.handle.net/1822/64289
DOI10.1016/j.biopsych.2005.08.020
ISSN0006-3223
e-ISSN1873-2402
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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