Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/64168

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dc.contributor.authorPereira, Carlapor
dc.contributor.authorBarreira, João C. M.por
dc.contributor.authorCalhelha, Ricardo C.por
dc.contributor.authorQueiroz, Maria João R. P.por
dc.contributor.authorBarros, Lillianpor
dc.contributor.authorFerreira, Isabel C. F. R.por
dc.date.accessioned2020-03-03T09:04:20Z-
dc.date.available2020-03-03T09:04:20Z-
dc.date.issued2014-
dc.identifier.issn2042-6496por
dc.identifier.urihttp://hdl.handle.net/1822/64168-
dc.description.abstractArtichoke (A), borututu (B) and milk thistle (M) are included in several supplements to provide beneficial effects. Different formulations (infusions, pills and syrups), with different proportions of A, B and M (1 : 1 : 1, 2 : 1 : 1, 1 : 2: 1, 1 : 1 : 2) within each formulation, were assayed to optimize the desired benefits. The antioxidant activity, anti-hepatocellular carcinoma activity, hepatotoxicity and bioactive compound contents were evaluated. Syrups tended to be the formulation with highest antioxidant activity and total phenolic and flavonoid content; otherwise, pills were the worst formulation. In what concerns A : B : M ratios, the results did not reveal so pronounced differences. None of the assayed mixtures resulted to be toxic (up to the maximum assayed dose) for liver primary cells (PLP2), but some samples, especially infusions, showed toxicity for the hepatocellular carcinoma cell line (HepG2). With no exception, the mixtures for all formulations showed synergistic effects on antioxidant activity, when compared to the activity of single plants.por
dc.description.sponsorshipThe authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). J. C. M. Barreira and R. C. Calhelha thank FCT, POPH-QREN and FSE for their grants (SFRH/BPD/68344/2010 and SFRH/BPD/72802/2010, respectively). L. Barros thanks "Compromisso para a Ciencia 2008" for her contract.por
dc.language.isoengpor
dc.publisherRoyal Society of Chemistrypor
dc.relationPEst-OE/AGR/UI0690/2011por
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72802%2F2010/PTpor
dc.rightsopenAccesspor
dc.titleNew insights into the effects of formulation type and compositional mixtures on the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plantspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2014/FO/C4FO00387Jpor
oaire.citationStartPage2052por
oaire.citationEndPage2060por
oaire.citationIssue9por
oaire.citationVolume5por
dc.identifier.doi10.1039/C4FO00387Jpor
dc.identifier.pmid25089364por
dc.subject.wosScience & Technologypor
sdum.journalFood & Functionpor
oaire.versionAMpor
Appears in Collections:CDQuim - Artigos (Papers)

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