Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/63920

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dc.contributor.authorPereira, Carlapor
dc.contributor.authorCalhelha, Ricardo C.por
dc.contributor.authorBarros, Lillianpor
dc.contributor.authorFerreira, Isabel C. F. R.por
dc.date.accessioned2020-02-14T09:46:38Z-
dc.date.available2020-02-14T09:46:38Z-
dc.date.issued2013-
dc.identifier.issn0926-6690por
dc.identifier.urihttp://hdl.handle.net/1822/63920-
dc.description.abstractCynara scolymus (artichoke), Silybum marianum (milk thistle) and Cochlospermum angolensis (borututu) are three plants widely used regarding hepatoprotective effects but to the best of our knowledge no anti-hepatocellular carcinoma activity has been studied in the most consumed forms: infusions and dietary supplements. Herein, antioxidant properties, anti-hepatocellular carcinoma activity and toxicity of infusions and dietary supplements of the mentioned plants were evaluated and compared. All the samples revealed antioxidant properties with EC50 values lower than the daily recommended dose, but infusions showed higher biological activity than dietary supplements. Borututu infusion gave the highest antioxidant activity (EC50 <= 170 mu g/mL), and also revealed anti-hepatocellular carcinoma activity (GI(50) = 146 mu g/mL) without toxicity in non-tumour liver cells (GI(50) > 400 mu g/mL). Artichoke infusion also presented antitumour activity (GI(50) = 52 mu g/mL) but with toxicity for normal cells at a higher concentration (GI(50) = 72 mu g/mL). The antioxidant and antitumour properties were positively correlated with phenolics and flavonoids content. Overall, among the three studied species, borututu infusion proved to be the most complete sample regarding antioxidant and anti-hepatocellular carcinoma activity.por
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to the research centre CIMO (PEst-OE/AGR/UI0690/2011). L. Barros also thanks to FCT, POPH-QREN and FSE for her grant (SFRH/BPD/4609/2008).por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectMedicinal plantspor
dc.subjectInfusions/Dietary supplementspor
dc.subjectAntioxidant activitypor
dc.subjectHepG2por
dc.subjectToxicitypor
dc.titleAntioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututupor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0926669013001921por
oaire.citationStartPage61por
oaire.citationEndPage65por
oaire.citationVolume49por
dc.identifier.essn1872-633Xpor
dc.identifier.doi10.1016/j.indcrop.2013.04.032por
dc.subject.wosScience & Technologypor
sdum.journalIndustrial Crops and Productspor
oaire.versionAMpor
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