Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/63920

TitleAntioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututu
Author(s)Pereira, Carla
Calhelha, Ricardo C.
Barros, Lillian
Ferreira, Isabel C. F. R.
KeywordsMedicinal plants
Infusions/Dietary supplements
Antioxidant activity
HepG2
Toxicity
Issue date2013
PublisherElsevier
JournalIndustrial Crops and Products
Abstract(s)Cynara scolymus (artichoke), Silybum marianum (milk thistle) and Cochlospermum angolensis (borututu) are three plants widely used regarding hepatoprotective effects but to the best of our knowledge no anti-hepatocellular carcinoma activity has been studied in the most consumed forms: infusions and dietary supplements. Herein, antioxidant properties, anti-hepatocellular carcinoma activity and toxicity of infusions and dietary supplements of the mentioned plants were evaluated and compared. All the samples revealed antioxidant properties with EC50 values lower than the daily recommended dose, but infusions showed higher biological activity than dietary supplements. Borututu infusion gave the highest antioxidant activity (EC50 <= 170 mu g/mL), and also revealed anti-hepatocellular carcinoma activity (GI(50) = 146 mu g/mL) without toxicity in non-tumour liver cells (GI(50) > 400 mu g/mL). Artichoke infusion also presented antitumour activity (GI(50) = 52 mu g/mL) but with toxicity for normal cells at a higher concentration (GI(50) = 72 mu g/mL). The antioxidant and antitumour properties were positively correlated with phenolics and flavonoids content. Overall, among the three studied species, borututu infusion proved to be the most complete sample regarding antioxidant and anti-hepatocellular carcinoma activity.
TypeArticle
URIhttp://hdl.handle.net/1822/63920
DOI10.1016/j.indcrop.2013.04.032
ISSN0926-6690
e-ISSN1872-633X
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0926669013001921
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
Carla ICP_Revised.pdf255,91 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID