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dc.contributor.authorAraújo, Ana Rita Rodriguespor
dc.contributor.authorCamero, Sérgiopor
dc.contributor.authorTaboada, Pablopor
dc.contributor.authorReis, R. L.por
dc.contributor.authorPires, R. A.por
dc.identifier.citationAraújo A. R., Gigante S. C., Taboada P., Reis R. L., Pires R. A. Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure, Chemical Communications (RSC), doi:10.1039/D0CC00192A, 2020por
dc.descriptionAccepted Manuscript ; "First published on 10 Feb 2020"por
dc.description.abstractThe isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.por
dc.description.sponsorshipWe acknowledge the financial support from the EC (FORECAST - 668983 and THE DISCOVERIES CTR – 739572), “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, Norte2020 TERM&SC, for the PhD grant NORTE-08-5369-FSE-000044; PT acknowledges Agencia Estatal de Investigación (AEI) for Project MAT2016-80266-R, and “Xunta de Galicia” for grants “Grupo de Referencia Competitiva” ED431C 2018/26 and “Agrupación Estratégica en Materiales-AEMAT” ED431E 2018/08, respectively. ERDF funds are also acknowledged.por
dc.publisherRoyal Society of Chemistrypor
dc.subjectAlzheimer's diseasepor
dc.subjectNatural polyphenolspor
dc.titleVescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structurepor
sdum.journalChemical Communicationspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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