Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/63909

TitleVescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
Author(s)Araújo, Ana Rita Rodrigues
Camero, Sérgio
Taboada, Pablo
Reis, R. L.
Pires, R. A.
KeywordsAlzheimer's disease
Amyloid-beta
Natural polyphenols
Issue dateFeb-2020
PublisherRoyal Society of Chemistry
JournalChemical Communications
CitationAraújo A. R., Gigante S. C., Taboada P., Reis R. L., Pires R. A. Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure, Chemical Communications (RSC), doi:10.1039/D0CC00192A, 2020
Abstract(s)The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.
TypeArticle
DescriptionAccepted Manuscript ; "First published on 10 Feb 2020"
URIhttp://hdl.handle.net/1822/63909
DOI10.1039/D0CC00192A
ISSN1359-7345
e-ISSN1364-548X
Publisher versionhttps://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc00192a/unauth#!divAbstract
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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