Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/63908

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dc.contributor.authorDias, Maria Inêspor
dc.contributor.authorBarreira, João C. M.por
dc.contributor.authorCalhelha, Ricardo C.por
dc.contributor.authorQueiroz, Maria João R. P.por
dc.contributor.authorOliveira, M. Beatriz P. P.por
dc.contributor.authorSoković, Marinapor
dc.contributor.authorFerreira, Isabel C. F. R.por
dc.date.accessioned2020-02-13T11:37:55Z-
dc.date.available2020-02-13T11:37:55Z-
dc.date.issued2014-
dc.identifier.issn2314-6133por
dc.identifier.urihttp://hdl.handle.net/1822/63908-
dc.description"Article ID 520464"por
dc.description.abstractNatural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples of L. nobilis were compared considering different phenolic groups. Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines. In general, the extract type induced the highest differences in bioactivity of laurel samples. However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the same response to laurel from wild and cultivated origin. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A. niger, A. fumigatus, and P. verrucosum. The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts. These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.por
dc.description.sponsorshipThe authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for the financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011) and REQUIMTE (PEst-C/EQB/LA0006/2011). M. I. Dias, R. Calhelha, and J. C. M. Barreira also thank FCT, POPHQREN, and FSE for their Grants (SFRH/BD/84485/2012, SFRH/BPD/ 68344/2010, and BPD/72802/2010). The authors also thank to Serbian Ministry of Education and Science for financial support (grant number 173032).por
dc.language.isoengpor
dc.publisherHindawi Limitedpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F84485%2F2012/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72802%2F2010/PTpor
dc.rightsopenAccesspor
dc.subjectAnti-Infective Agentspor
dc.subjectAntineoplastic Agentspor
dc.subjectBacteriapor
dc.subjectCell Line, Tumorpor
dc.subjectDrug Screening Assays, Antitumorpor
dc.subjectFungipor
dc.subjectHumanspor
dc.subjectLauruspor
dc.subjectMethanolpor
dc.subjectMicrobial Sensitivity Testspor
dc.subjectPhenolspor
dc.subjectPlant Extractspor
dc.subjectPrincipal Component Analysispor
dc.titleTwo-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different originspor
dc.typearticlepor
dc.peerreviewedyespor
oaire.citationStartPage1por
oaire.citationEndPage10por
oaire.citationVolume2014por
dc.identifier.essn2314-6141por
dc.identifier.doi10.1155/2014/520464por
dc.identifier.pmid24826380por
dc.subject.wosScience & Technologypor
sdum.journalBiomed Research Internationalpor
oaire.versionVoRpor
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