Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/63827

TitleThe extracellular proteins of Lactobacillus acidophilus DSM 20079T display anti-inflammatory effect in both in piglets, healthy human donors and Crohns Disease patients
Author(s)Hidalgo-Cantabrana, Claudio
Marco Antonio Moro-García
Aitor Blanco-Míguez
Florentino Fdez-Riverola
Mamen Oliván
Luis J. Royo
Sabino Riestra
Abelardo Margolles
Lourenço, Anália
Rebeca Alonso-Arias
Borja Sánchez
KeywordsExtracellular proteins
Tolerance
Anti-inflammatory
Treg
Innate immune system
Issue date2020
PublisherElsevier
JournalJournal of Functional Foods
CitationHidalgo-Cantabrana, Claudio; Marco Antonio Moro-García; Aitor Blanco-Míguez; Florentino Fdez-Riverola; Mamen Oliván; Luis J. Royo; Sabino Riestra; Abelardo Margolles; Lourenço, Anália; Rebeca Alonso-Arias; Borja Sánchez, The extracellular proteins of Lactobacillus acidophilus DSM 20079T display anti-inflammatory effect in both in piglets, healthy human donors and Crohns Disease patients. Journal of Functional Foods, 64(103660), 2020
Abstract(s)Lactobacillus genus includes both probiotic and representative strains of the human gut microbiota. Independent studies have reported on the anti-inflammatory properties of different Lactobacillus strains, although we are far from understanding the underlying molecular interplay. In this work we show that a daily administration of Lactobacillus acidophilus DSM20079T (DSM20079) to healthy piglets resulted in plasmatic increases of the anti-inflammatory IL10, whilst IL12 and the pro-inflammatory ratio IL12+TNF/IL10 decreased. The extracellular protein fraction of DSM20079 was identified as the responsible for the crosstalk interaction that elicited these tolerogenic effects. This strain was able to activate innate immune pathways in dendritic cells and to decrease the production of pro-inflammatory cytokines in both CD4+/CD8+ T cell subsets in healthy donors and in Crohns Disease patients. The tolerogenic effect exerted by the extracellular proteins of this strain suggests their potential use as coadjutant for therapeutic applications targeting chronic inflammatory illnesses.
TypeArticle
URIhttp://hdl.handle.net/1822/63827
DOI10.1016/j.jff.2019.103660
ISSN1756-4646
Publisher versionhttps://www.journals.elsevier.com/journal-of-functional-foods
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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