Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/6362

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dc.contributor.authorRodrigues, L. R.-
dc.contributor.authorBanat, Ibrahim M.-
dc.contributor.authorTeixeira, J. A.-
dc.contributor.authorOliveira, Rosário-
dc.date.accessioned2007-05-07T21:20:34Z-
dc.date.available2007-05-07T21:20:34Z-
dc.date.issued2007-05-
dc.identifier.citation"Journal of biomedical materials research part B : applied biomaterials". ISSN 1552-4973. 81B:2 (May 2007) 358-370.eng
dc.identifier.issn1552-4973eng
dc.identifier.urihttp://hdl.handle.net/1822/6362-
dc.description.abstractTotal laryngectomy, a surgical treatment for extensive cancer of larynx, which alters swallowing and respiration in patients, is followed up with a surgical voice restoration procedure comprising tracheoesophageal puncture techniques with insertion of a ‘‘voice prosthesis’’ to improve successful voice rehabilitation. However, microbial colonization is a major drawback of these devices. Antimicrobials are usually used to prevent the colonization of silicone rubber voice prostheses by microorganisms. However, long-term medication induces the development of resistant strains with all associated risks and the development of alternative prophylactic and therapeutic agents, including probiotics and biosurfactants, have been suggested. The inhibition of microbial growth on surfaces can also be achieved by several other techniques involving the modification of physicochemical properties of the biomaterial surface or the covalently binding of antimicrobial agents to the biomaterial surface. An overview of the different approaches investigated to date and future perspectives to reduce the frequent replacements of voice prostheses in laryngectomized patients through microbial biofilm retardation is presented and discussed.eng
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)por
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsopenAccesseng
dc.subjectVoice prosthesiseng
dc.subjectBiofilmeng
dc.subjectProphylactic treatmenteng
dc.subjectSurface modificationseng
dc.subjectBiosurfactantseng
dc.titleStrategies for the prevention of microbial biofilm formation on silicone rubber voice prostheseseng
dc.typearticlepor
dc.peerreviewedyeseng
sdum.number2eng
sdum.pagination358-370eng
sdum.publicationstatuspublishedeng
sdum.volume81Beng
oaire.citationStartPage358por
oaire.citationEndPage370por
oaire.citationIssue2por
oaire.citationVolume81Bpor
dc.identifier.doi10.1002/jbm.b.30673por
dc.identifier.pmid17022068por
dc.subject.wosScience & Technologypor
sdum.journalJournal of Biomedical Materials Research Part B: Applied Biomaterialspor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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