Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62871
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Calejo, I. | por |
dc.contributor.author | Costa-Almeida, R. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2020-01-06T09:31:03Z | - |
dc.date.available | 2020-01-06T09:31:03Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2019 | - |
dc.identifier.citation | Calejo I., Costa-Almeida R., Reis R. L., Gomes M. E. A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering, Trends in Biotechnology, Vol. 38, Issue 1, pp. 83-98, doi:10.1016/j.tibtech.2019.06.003, 2020. | por |
dc.identifier.issn | 0167-7799 | por |
dc.identifier.uri | https://hdl.handle.net/1822/62871 | - |
dc.description.abstract | Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native interfaces and tissue regeneration is unlikely to occur. Tissue engineering strategies are emerging to emulate the physiological environment of soft-to-hard tissue interfaces. Advances in biomaterial design enable control over biophysical parameters, but biomaterials alone are not sufficient to provide adequate support and guide transplanted cells. Therefore, biological, biophysical, and biochemical tools can be integrated into a multifactorial toolbox, steering prospective advances toward engineering clinically relevant soft-to-hard tissue interfaces. | por |
dc.description.sponsorship | The authors acknowledge the financial support from the European Union Framework Programme for Research and Innovation HORIZON2020 (TEAMING Grant agreement, No 739572 - The Discoveries CTR), the ERC Grant CoG MagTendon (nr 772817), Fundação para a Ciência e a Tecnologia (FCT) for the PhD grant of I.C. (PD/BD/128088/2016), and the Project NORTE-01-0145-FEDER-000021 through the European Regional Development Fund (ERDF). | por |
dc.language.iso | eng | por |
dc.publisher | Cell Press | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/739572/EU | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/772817/EU | por |
dc.relation | PD/BD/128088/2016 | por |
dc.rights | openAccess | por |
dc.subject | biomaterial design | por |
dc.subject | Biomimetics | por |
dc.subject | gradients | por |
dc.subject | multitissue transitions | por |
dc.subject | regenerative medicine | por |
dc.subject | stem cell differentiation | por |
dc.title | A physiology-inspired multifactorial toolbox in soft-to-hard musculoskeletal interface tissue engineering | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0167779919301520 | por |
dc.comments | http://3bs.uminho.pt/node/19955 | por |
oaire.citationStartPage | 83 | por |
oaire.citationEndPage | 98 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 38 | por |
dc.date.updated | 2020-01-03T19:44:47Z | - |
dc.identifier.doi | 10.1016/j.tibtech.2019.06.003 | por |
dc.identifier.pmid | 31320120 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Trends in Biotechnology | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19955-1-s2.0-S0167779919301520-main.pdf | 5,2 MB | Adobe PDF | Ver/Abrir |