Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62828

TitlePrevalence of thyroiditis and immunohistochemistry study searching for a morphologic consensus in morphology of autoimmune thyroiditis in a 4613 autopsies series
Author(s)Vecchiatti, Stella M. P.
Lin, Chin Jia
Capelozzi, Vera L.
Longatto, Adhemar
Bisi, Hélio
KeywordsAdolescent
Adult
Aged
Aged, 80 and over
Antigens, CD
Apoptosis
Autopsy
Biomarkers
Brazil
Caspase 3
Child
Child, Preschool
Female
Gene Expression
Hashimoto Disease
Humans
Immunohistochemistry
In Situ Nick-End Labeling
Infant
Infant, Newborn
Male
Middle Aged
Prevalence
Retrospective Studies
Terminology as Topic
Thyroid Gland
Thyroiditis, Autoimmune
thyroiditis
apoptosis Hashimoto disease
Issue dateJul-2015
PublisherLippincott, Williams & Wilkins
JournalApplied Immunohistochemistry & Molecular Morphology
CitationVecchiatti, S. M., Lin, C. J., Capelozzi, V. L., Longatto-Filho, A., & Bisi, H. (2015). Prevalence of thyroiditis and immunohistochemistry study searching for a morphologic consensus in morphology of autoimmune thyroiditis in a 4613 autopsies series. Applied Immunohistochemistry & Molecular Morphology, 23(6), 402-408
Abstract(s)We sought to verify the prevalence of lymphocytic thyroiditis (LT) and Hashimoto's thyroiditis (HT) in autopsy materials. Cases examined between 2003 and 2007 at the Department of Pathology of Faculty of Medicine of São Paulo University were studied. Immunohistochemical analyses were conducted in selected cases to characterize the type of infiltrating mononuclear cells; in addition, we evaluated the frequency of apoptosis by TUNEL assay technique and caspase-3 immunostaining. Significant increase in overall thyroiditis frequency was observed in the present series when compared with the previous report (2.2978% vs. 0.0392%). Thyroiditis was more prevalent among older people. Selected cases of LT and HT (40 cases each) had their infiltrating lymphocytes characterized by immunohistochemical analyses. Both LT and HT showed similar immunostaining patterns for CD4, CD8, CD68, thus supporting a common pathophysiology mechanism and indicating that LT and HT should be considered different presentations of a same condition, that is, autoimmune thyroiditis. Moreover, apoptosis markers strongly evidenced that apoptosis was present in all studied cases. Our results demonstrated an impressive increase in the prevalence of thyroiditis during recent years and our data support that the terminology of autoimmune thyroiditis should be used to designate both LT and HT. This classification would facilitate comparison of prevalence data from different series and studies.
TypeArticle
URIhttp://hdl.handle.net/1822/62828
DOI10.1097/PAI.0000000000000094
ISSN1541-2016
e-ISSN1533-4058
Publisher versionhttps://insights.ovid.com/article/00129039-201507000-00002
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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