Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier

doi:10.1016/j.colsurfb.2019.06.041

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/62605

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Campo DC	Valor	Idioma
dc.contributor.author	Choi, J. H.	por
dc.contributor.author	Choi, O. K.	por
dc.contributor.author	Lee, J.	por
dc.contributor.author	Noh, J.	por
dc.contributor.author	Lee, S.	por
dc.contributor.author	Park, A.	por
dc.contributor.author	Rim, M. A.	por
dc.contributor.author	Reis, R. L.	por
dc.contributor.author	Gilson, K.	por
dc.date.accessioned	2019-12-10T09:43:43Z	-
dc.date.available	2019-12-10T09:43:43Z	-
dc.date.issued	2019-06	-
dc.date.submitted	2019-12	-
dc.identifier.citation	Choi J. H., Choi O. K., Lee J., Noh J., Lee S., Park A., Rim M. A., Reis R. L., Gilson K. Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier, Colloids And Surfaces B : Biointerfaces, Vol. 181, pp. 879-889, doi:10.1016/j.colsurfb.2019.06.041, 2019	por
dc.identifier.issn	0927-7765	por
dc.identifier.uri	https://hdl.handle.net/1822/62605	-
dc.description	Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.colsurfb.2019.06.041.	por
dc.description.abstract	In this study, a double network hydrogel of a natural polysaccharide gellan gum (GG) hydrogel and a synthetic hydrogel poloxamer-heparin (PoH) hydrogel (PoH/GG DNH) is introduced to complement disadvantages of each hydrogel and improve the microenvironment for cell delivery. The microstructure, surface morphology, gelation temperature, swelling and weight loss, sol fraction, mechanical property and thermal stability was examined. The potential of the composite hydrogel for cell vehicle was demonstrated by encapsulation of bone marrow stem cells isolated from rabbits (rBMSCs) within the PoH/GG DNH in vitro. The results showed that the DNH system supported cell survival and retained rBMSCs morphology and phenotype. Moreover, cell distribution, adherence, and ECM production were supported by PoH/GG DNH in vivo. Overall results provide a potential opportunity to apply the composite hydrogels in tissue engineering purpose.	por
dc.description.sponsorship	This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C2996) and a grant of theKoreaHealthTechnology R&D Project through KHIDI (HI15C2996).	por
dc.language.iso	eng	por
dc.publisher	Elsevier 1	por
dc.rights	openAccess	por
dc.subject	bone marrow stem cells	por
dc.subject	Double network hydrogel	por
dc.subject	hydrogel	por
dc.subject	Nature-derived	por
dc.subject	regeneration	por
dc.subject	Synthetic	por
dc.title	Evaluation of double network hydrogel of poloxamer-heparin/gellan gum for bone marrow stem cells delivery carrier	por
dc.type	article	-
dc.peerreviewed	yes	por
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0927776519304473	por
dc.comments	http://3bs.uminho.pt/node/19989	por
oaire.citationStartPage	879	por
oaire.citationEndPage	889	por
oaire.citationVolume	181	por
dc.date.updated	2019-12-10T09:39:13Z	-
dc.identifier.doi	10.1016/j.colsurfb.2019.06.041	por
dc.identifier.pmid	31382336	por
dc.subject.wos	Science & Technology	por
sdum.journal	Colloids And Surfaces B : Biointerfaces	por
Aparece nas coleções:	3B’s - Artigos em revistas/Papers in scientific journals