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TitleImpact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: the quality of liquid-based preparation of cytological slides
Author(s)Mariano, Vânia S.
Pastrez, Paula R. A.
Mafra Costa, Allini
Guimarães, Denise P.
Cunha, Thiago R.
Neto, Said A. Z.
Scapulatempo-Neto, Christóvam
Syrjänen, Kari J.
Longatto, Adhemar
Cross-Sectional Studies
Cytological Techniques
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma
Middle Aged
Preservatives, Pharmaceutical
Prospective Studies
Sensitivity and Specificity
Tissue Preservation
Esophageal squamous cell cancer
Brush cytology
Liquid-based cytology
Issue date2019
PublisherKarger Publishers
JournalActa Cytologica
CitationMariano, V. S., Pastrez, P. R., Costa, A. M., et. al. (2019). Impact of Brush Cytology Analysis for the Diagnosis of Esophageal Squamous Cell Carcinoma: The Quality of Liquid-Based Preparation of Cytological Slides. Acta cytologica, 63(3), 240-246.
Abstract(s)The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. bjectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduodenoscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.
Publisher version
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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