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|Title:||Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: the quality of liquid-based preparation of cytological slides|
|Author(s):||Mariano, Vânia S.|
Pastrez, Paula R. A.
Mafra Costa, Allini
Guimarães, Denise P.
Cunha, Thiago R.
Neto, Said A. Z.
Syrjänen, Kari J.
Esophageal Squamous Cell Carcinoma
Sensitivity and Specificity
Esophageal squamous cell cancer
|Citation:||Mariano, V. S., Pastrez, P. R., Costa, A. M., et. al. (2019). Impact of Brush Cytology Analysis for the Diagnosis of Esophageal Squamous Cell Carcinoma: The Quality of Liquid-Based Preparation of Cytological Slides. Acta cytologica, 63(3), 240-246.|
|Abstract(s):||The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. bjectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduodenoscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.|
|Access:||Restricted access (Author)|
|Appears in Collections:||ICVS - Artigos em Revistas Internacionais com Referee|
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