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TitleClinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
Author(s)Afonso, Julieta Alexandra Pereira
Pinto, Tatiana
Sousa, Susana Patrícia Simões
Schmitt, Fernando
Longatto, Adhemar
Pinheiro, Céline
Marques, Herlander
Baltazar, Fátima
KeywordsNon-Hodgkin lymphoma
Diffuse large B cell lymphoma
Warburg effect
Monocarboxylate transporters
Metabolic symbiosis
Issue dateJun-2019
JournalCellular Oncology
CitationAfonso, J., Pinto, T., Simões-Sousa, S., Schmitt, F., Longatto-Filho, A., Pinheiro, C., ... & Baltazar, F. (2019). Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma–MCT1 as potential target in diffuse large B cell lymphoma. Cellular Oncology, 1-16
Abstract(s)Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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