Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62437

TitleIn vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
Author(s)Lee, Sang Jin
Kim, Han-Jun
Heo, Min
Lee, Hye-Rim
Choi, Eun-Ji
Kim, Hyosung
Lee, Donghyun
Reis, R. L.
Do, Sun Hee
Kwon, Il Keun
KeywordsElectrospinning
Gelatin
Highly aligned nanofiber
Polycaprolactone
Tendon tissue engineering applications
Issue dateMar-2019
PublisherElsevier
JournalJournal of Industrial and Engineering Chemistry
CitationLee S. J., Kim H. - J., Heo M., Lee H. - R., Choi E. - J., Kim H., Lee D., Reis R. L., Do S. H., Kwon I. K. In vitro and In vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for achilles tendon tissue engineering, Journal of Industrial and Engineering Chemistry, Vol. 76, pp. 173-180, doi:10.1016/j.jiec.2019.03.036, 2019
Abstract(s)In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.
TypeArticle
URIhttp://hdl.handle.net/1822/62437
DOI10.1016/j.jiec.2019.03.036
ISSN1226-086X
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S1226086X19301236
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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