Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62352

TitleDynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin
Author(s)Lord, Louis-David
Expert, Paul
Atasoy, Selen
Roseman, Leor
Rapuano, Kristina
Lambiotte, Renaud
Nutt, David J.
Deco, Gustavo
Carhart-Harris, Robin L.
Kringelbach, Morten L.
Cabral, Joana
Issue date2019
PublisherElsevier
JournalNeuroimage
CitationLord, L. D., Expert, P., Atasoy, S., Roseman, L., Rapuano, K.,et. al.(2019). Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin. NeuroImage, 199, 127-142.
Abstract(s)Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in "magic mushrooms". We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session. Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.
TypeArticle
URIhttp://hdl.handle.net/1822/62352
DOI10.1016/j.neuroimage.2019.05.060
ISSN1053-8119
e-ISSN1095-9572
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S1053811919304525
Peer-Reviewedyes
AccessEmbargoed access (3 Years)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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