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TitleNanoparticle delivery systems in the treatment of diabetes complications
Author(s)Souto, Eliana
Souto, Selma B.
Campos, Joana R.
Severino, Patricia
Pashirova, Tatiana N.
Zakharova, Lucia Y.
Silva, Amélia M.
Durazzo, Alessandra
Lucarini, Massimo
Izzo, Angelo A.
Santini, Antonello
Keywordsdiabetes mellitus
drug delivery systems
oral hypoglycemic agents
Issue date20-Nov-2019
CitationSouto, Eliana; Souto, Selma B.; Campos, Joana R.; Severino, Patricia; Pashirova, Tatiana N.; Zakharova, Lucia Y.; Silva, Amélia M.; Durazzo, Alessandra; Lucarini, Massimo; Izzo, Angelo A.; Santini, Antonello, Nanoparticle delivery systems in the treatment of diabetes complications. Molecules, 24(23), 4209, 2019
Abstract(s)Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line treatment. This administration route is however associated with limited patients compliance, due to the risk of pain, discomfort and local infection. Nanoparticles have been proposed as insulin carriers to make possible the administration of the peptide via friendlier pathways without the need of injection, i.e., via oral or nasal routes. Nanoparticles stand for particles in the nanometer range that can be obtained from different materials (e.g., polysaccharides, synthetic polymers, lipid) and are commonly used with the aim to improve the physicochemical stability of the loaded drug and thereby its bioavailability. This review discusses the use of different types of nanoparticles (e.g., polymeric and lipid nanoparticles, liposomes, dendrimers, niosomes, micelles, nanoemulsions and also drug nanosuspensions) for improved delivery of different oral hypoglycemic agents in comparison to conventional therapies.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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