Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62345

TitleNanoparticle delivery systems in the treatment of diabetes complications
Author(s)Souto, Eliana
Souto, Selma B.
Campos, Joana R.
Severino, Patricia
Pashirova, Tatiana N.
Zakharova, Lucia Y.
Silva, Amélia M.
Durazzo, Alessandra
Lucarini, Massimo
Izzo, Angelo A.
Santini, Antonello
Keywordsdiabetes mellitus
insulin
nanoparticles
drug delivery systems
oral hypoglycemic agents
Issue date20-Nov-2019
PublisherMDPI
JournalMolecules
CitationSouto, Eliana; Souto, Selma B.; Campos, Joana R.; Severino, Patricia; Pashirova, Tatiana N.; Zakharova, Lucia Y.; Silva, Amélia M.; Durazzo, Alessandra; Lucarini, Massimo; Izzo, Angelo A.; Santini, Antonello, Nanoparticle delivery systems in the treatment of diabetes complications. Molecules, 24(23), 4209, 2019
Abstract(s)Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line treatment. This administration route is however associated with limited patients compliance, due to the risk of pain, discomfort and local infection. Nanoparticles have been proposed as insulin carriers to make possible the administration of the peptide via friendlier pathways without the need of injection, i.e., via oral or nasal routes. Nanoparticles stand for particles in the nanometer range that can be obtained from different materials (e.g., polysaccharides, synthetic polymers, lipid) and are commonly used with the aim to improve the physicochemical stability of the loaded drug and thereby its bioavailability. This review discusses the use of different types of nanoparticles (e.g., polymeric and lipid nanoparticles, liposomes, dendrimers, niosomes, micelles, nanoemulsions and also drug nanosuspensions) for improved delivery of different oral hypoglycemic agents in comparison to conventional therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/62345
DOI10.3390/molecules24234209
ISSN14203049
Publisher versionhttps://www.mdpi.com/journal/molecules
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_52211_1.pdf956,24 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID