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dc.contributor.authorVale, A. Catarinapor
dc.contributor.authorPereira, Paulo R.por
dc.contributor.authorBarbosa, Ana Margarida Martinspor
dc.contributor.authorTorrado, Egídiopor
dc.contributor.authorAlves, N. M.por
dc.description.abstractBioglass nanoparticles (BGs) are of outmost importance in the biomedical field, because their unique characteristics, namely osteoconductivity and osteoinductivity, and also in certain conditions, angiogenic and bactericidal properties. In this work, novel bioglass nanoparticles containing silver (AgBGs) were synthesized by a sol-gel method, adopting different thermal treatments to obtain new nanoparticles with bioactive and antibacterial features. This is the first systematic study of the effect of the thermal treatment on the properties of AgBGs. The effect of the studied thermal treatments on the properties of synthesized nanoparticles was analyzed by several characterization techniques: FT-IR, XRD, S-TEM, SEM-EDS and Zeta potential. FT-IR allowed the identification of the characteristic peaks of the nanoparticles and XRD revealed the presence of the characteristic peaks of an apatite-like phase. By S-TEM analysis it was found that the produced nanoparticles are dense and have a diameter <200 nm. The SEM micrographs showed their surface morphology and Zeta potential measurements were performed to study their suspension stability. Additionally, in vitro bioactivity tests confirmed their bioactive potential and the microbiological tests evidenced their bactericidal effect. These promising AgBGs could be incorporated either in 2D or 3D structures for several biomedical applications, namely in the orthopedic and dental fields.por
dc.description.sponsorshipThe authors acknowledge the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/COMPETE for the financial support through projects PTDC/BTM-MAT/28123/ 2017 and PTDC/NAN-MAT/31036/2017.por
dc.rightsembargoedAccess (1 Year)por
dc.subjectAnti-Bacterial Agentspor
dc.subjectBiomedical Technologypor
dc.subjectMetal Nanoparticlespor
dc.subjectMicrobial Sensitivity Testspor
dc.subjectSpectroscopy, Fourier Transform Infraredpor
dc.subjectStatic Electricitypor
dc.subjectX-Ray Diffractionpor
dc.subjectBioglass® (BG)por
dc.subjectSilver (Ag)por
dc.subjectAntibacterial activitypor
dc.subjectBioglass (R) (BG)por
dc.titleOptimization of silver-containing bioglass nanoparticles envisaging biomedical applicationspor
dc.subject.wosScience & Technologypor
sdum.journalMaterials Science & Engineering: C Materials for Biological Applicationspor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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