Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62192
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Syrjänen, Stina | por |
dc.contributor.author | Longhato, Adhemar | por |
dc.contributor.author | Sarian, Luis O. | por |
dc.contributor.author | Naud, Paulo | por |
dc.contributor.author | Derchain, Sophie | por |
dc.contributor.author | Rottelli-Martins, Cecilia | por |
dc.contributor.author | Tatti, Silvio | por |
dc.contributor.author | Branca, Margherita | por |
dc.contributor.author | Eržen, Mojca | por |
dc.contributor.author | Hammes, Luciano S. | por |
dc.contributor.author | Matos, Jean | por |
dc.contributor.author | Gontijo, Renata | por |
dc.contributor.author | Bragança, Joana | por |
dc.contributor.author | Arlindo, Francisco C. | por |
dc.contributor.author | Maeda, Mariana Y. S. | por |
dc.contributor.author | Costa, Silvano | por |
dc.contributor.author | Syrjänen, Kari | por |
dc.date.accessioned | 2019-11-18T15:12:21Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | Syrjänen, S., Longhato-Filho, A., Sarian, L. O., et. al. (2013). Competing-risks regression models in analysis of biomarkers as predictors of high-risk human papillomavirus (HPV) infection outcomes and incident CIN in the LAMS cohort. International Journal of Gynecological Pathology, 32(4), 406-415. | por |
dc.identifier.issn | 0277-1691 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62192 | - |
dc.description.abstract | To assess the prediction potential of a 5-biomarker panel for detecting high-risk human papillomavirus (HR-HPV) infections and/or cervical intraepithelial neoplasia (CIN) progression. Five biomarkers, lipocalin, plasminogen activator inhibitor-2, p300, interleukin-10, and stratifin, were assessed in cervical biopsies from 225 women of the Latin American Screening Study. Competing-risks regression models were constructed to assess their predictive power for (i) HR-HPV outcomes (negative, transient, or persistent infection) and (ii) CIN outcomes (no progression, incident CIN1, CIN2, or CIN3). p300, LCN2, stratifin were significantly associated with prevalent HR-HPV but lost their significance in multivariate analysis. In the multivariate model, only p300 was an independent predictor of CIN3 (odds ratio=2.63; 95% confidence interval, 1.05-6.61; P=0.039). In univariate competing-risks regression, lipocalin predicted permanent HR-HPV-negative status, but in the multivariate model, IL-10 emerged as a independent predictor of HPV-negative status (subhazard ratio=4.04; 95% confidence interval, 1.81-9.01; P=0.001). The clinical value of the panel in predicting longitudinal outcomes of HR-HPV infection and/or incident CIN is limited. | por |
dc.description.sponsorship | Supported by the European Commission, INCO-DEV Programme (Contract# ICA4-CT-2001-10013). | por |
dc.language.iso | eng | por |
dc.publisher | Lippincott, Williams & Wilkins | por |
dc.rights | closedAccess | por |
dc.subject | 14-3-3 Proteins | por |
dc.subject | Biomarkers | por |
dc.subject | Biomarkers, Tumor | por |
dc.subject | Cervical Intraepithelial Neoplasia | por |
dc.subject | Cervix Uteri | por |
dc.subject | Cohort Studies | por |
dc.subject | DNA, Viral | por |
dc.subject | Disease Progression | por |
dc.subject | E1A-Associated p300 Protein | por |
dc.subject | Exoribonucleases | por |
dc.subject | Female | por |
dc.subject | Humans | por |
dc.subject | Interleukin-10 | por |
dc.subject | Lipocalins | por |
dc.subject | Longitudinal Studies | por |
dc.subject | Multivariate Analysis | por |
dc.subject | Papillomaviridae | por |
dc.subject | Papillomavirus Infections | por |
dc.subject | Predictive Value of Tests | por |
dc.subject | Prognosis | por |
dc.subject | Prospective Studies | por |
dc.subject | Serpins | por |
dc.subject | Uterine Cervical Neoplasms | por |
dc.subject | High-risk HPV | por |
dc.subject | Incident CIN | por |
dc.subject | Viral outcomes | por |
dc.subject | Lipocalin | por |
dc.subject | PAI-2 (Serpin-B2) | por |
dc.subject | p300 | por |
dc.subject | IL-10 | por |
dc.subject | Stratifin (14-3-3) | por |
dc.subject | Competing-risks regression | por |
dc.subject | Predictors | por |
dc.subject | Longitudinal setting | por |
dc.subject | Longitudinal settingHigh-risk HPV | por |
dc.subject | Stratifin (14-3-3s) | por |
dc.title | Competing-risks regression models in analysis of biomarkers as predictors of high-risk human papillomavirus (HPV) infection outcomes and incident CIN in the LAMS cohort | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://journals.lww.com/intjgynpathology/Abstract/2013/07000/Competing_Risks_Regression_Models_in_Analysis_of.10.aspx | por |
oaire.citationStartPage | 406 | por |
oaire.citationEndPage | 415 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 32 | por |
dc.identifier.eissn | 1538-7151 | - |
dc.identifier.doi | 10.1097/PGP.0b013e31826739b1 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 23722514 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Gynecological Pathology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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10.1097@PGP.0b013e31826739b1.pdf Acesso restrito! | 151,46 kB | Adobe PDF | Ver/Abrir |