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TitleMacro- and micro-structural white matter differences correlate with cognitive performance in healthy aging
Author(s)Marques, Paulo César Gonçalves
Soares, José Miguel Montenegro
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
Aged, 80 and over
Cluster Analysis
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Middle Aged
Organ Size
Principal Component Analysis
Psychological Tests
White Matter
Cognitive performance
Tract-based spatial statistics
Issue dateMar-2016
JournalBrain Imaging and Behavior
CitationMarques, P. C. G., Soares, J. M. M., da Silva Magalhães, R. J., Santos, N. C., & Sousa, N. J. C. (2016). Macro-and micro-structural white matter differences correlate with cognitive performance in healthy aging. Brain imaging and behavior, 10(1), 168-181.
Abstract(s)Studies have shown that white matter (WM) volumetric reductions and overall degradation occur with aging. Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals. The main goal of the present work was to identify and characterize possible macro and microstructural WM alterations that could distinguish between older healthy individuals with contrasting cognitive profiles (i.e., "poor" vs "good" cognitive performers). Structural and diffusion magnetic resonance imaging was performed in order to quantify local WM volumes, white matter signal abnormalities (WMSA) volume (a measure of lesion burden) and diffusion tensor imaging scalar maps known to probe WM microstructure. A battery of neurocognitive/psychological tests was administered to assess the cognitive performance. Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers. Even when controlling for WMSA volume, poor performers also evidenced lower fractional anisotropy, as well as positive associations with age with higher slopes of regression parameters in radial and axial diffusivity. Altogether results suggest that cognitive performance is related to differences in WM, with poor cognitive performers displaying signs of faster aging in WM.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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