Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/62007

TitleOxidative stress profiles in brain point out a higher susceptibility of fish to waterborne divalent mercury compared to dietary organic mercury
Author(s)Cardoso, Olívia
Puga, Sónia Andreia Silva
Brandão, Fátima
Canário, João
O'Driscoll, Nelson J.
Santos, Maria Ana
Pacheco, Mário
Pereira, Patrícia
KeywordsAnimals
Brain
Mercury
Methylmercury Compounds
Water Pollutants, Chemical
Fishes
Oxidative Stress
Inorganic mercury
Neurotoxicity
Methylmercury
Fish
Issue date15-Sep-2017
PublisherElsevier
JournalMarine Pollution Bulletin
Abstract(s)This study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28days of depuration, which did not occur for Hg(II). Moreover, Hg(II) displayed a high neurotoxicity potential, as unveiled by the poor activation of brain antioxidant defenses and recurrent oxidative damage (as protein oxidation), while the opposite was recorded upon MeHg exposure. These results highlight the need to include Hg(II) in future environmental health assessment plans, preventing an underestimation of the risk for wild fish populations, which has probably been occurring due to the long-standing idea of the higher toxicity of MeHg in comparison with inorganic Hg forms.
TypeArticle
URIhttp://hdl.handle.net/1822/62007
DOI10.1016/j.marpolbul.2017.06.029
ISSN0025-326X
e-ISSN1879-3363
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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